Inregen

Prokidney

Tengion, Inc.

University of North Carolina at Chapel Hill

Vesta Therapeutics Inc.

National Oilwell Varco, L.p.

Regenmedtx, LLC

Regenmed, Inc.

Incara Cell Technologies, Inc.

Andrew T Bruce

John W Ludlow

Russell W Kelley

Manuel J Jayo

Timothy A Bertram

Oluwatoyin A Knight

Sharon C Presnell

Roger M Ilagan

Joydeep Basu

Kelly Guthrie

Sumana Choudhury

Shay M Wallace

Eric S Werdin

Deepak Jain

Richard Payne

Namrata D Sangha

Darell McCoy

Christopher W Genheimer

H Scott Rapoport

Craig R Halberstadt

Teresa Burnette

Neil F Robins

Elias A Rivera

Thomas Spencer

Benjamin Watts

Bryan R Cox

Jessica J Reinsch

Patricia D Tatsumi

Dominic Justewicz

Lola M Reid

Mark E Furth

Nicholas Moss

David Reid

Tony Pink

Rusty Kelley

Nicholas G Moss

Darrell Mccoy

Kelly I Guthrie

Russell W Keller

Scott H Rapoport

Russel W Kelley

The present invention concerns enriched heterogeneous mammalian renal cell populations characterized by biomarkers, and methods of making and using the same.

Renal cell populations and uses thereof

The present invention concerns bioactive renal cell populations, renal cell constructs, and methods of making and using the same.

Bioactive renal cells

The present invention concerns bioactive renal cells populations, renal cell constructs, and methods of making and using the same.

The invention is directed to isolated renal cells, including tubular and erythropoietin (EPO)-producing kidney cell populations, and methods of isolating and culturing the same, as well as methods of treating a subject in need with the cell populations.

Isolated renal cells and uses thereof

A drilling system comprises a drilling parameter sensor in communication with a sensor applicationthat generates processed data from raw data that is received from the drilling parameter sensor. A process applicationis in communication with the sensor applicationand generates an instruction based on the processed data. A priority controller is in communication with the process applicationand evaluates the instruction for release to an equipment controllerthat then issues the instruction to one or more drilling components.

Automated drilling system

Biocompatible synthetic or natural scaffolds are provided for the reconstruction, repair, augmentation or replacement of organs or tissue structures in a patient in need of such treatment. The scaffolds are shaped to conform to at least a part of the organ or tissue structure and may be seeded with one or more cell populations. Inserts, receptacles and ports are also provided for the attachment of tubular vessels to the neo-organ scaffolds. The seeded scaffolds are implanted into the patient at the site in need of treatment to form an organized organ or tissue structure. The scaffolds may be used to form organs or tissues, such as bladders, urethras, valves, and blood vessels.

Scaffolds for organ reconstruction and augmentation

Hepatic progenitors comprise two populations of human hepatic stem cells, primitive and proximal hepatic stem cells, and two populations of committed progenitors, one for biliary cells and one for hepatocytes. Human primitive hepatic stem cells are a very small fraction of the liver cell population and give rise to proximal hepatic stem cells constituting a much larger fraction of the liver. Human proximal hepatic stem cells give rise to biliary and hepatocyte committed progenitors. Primitive and proximal stem cells are the primary stem cells for the human liver. Human primitive hepatic stem cells may be isolated by immunoselection from human livers or culturing human liver cells under conditions which select for a human primitive hepatic stem cell. Proximal hepatic stem cells may be isolated by immunoselection, or by culturing human liver cells under conditions which include a developmental factor. Proximal hepatic stem cells may also be isolated by culturing colonies comprising a primitive hepatic stem cell under conditions which include a developmental factor. Resulting compositions may be used for treating liver disorders and for producing bioartificial organs.

Primitive and proximal hepatic stem cells

Growing community of inventors

Lexington, NC, United States of America

Andrew T Bruce