The Cleveland Clinic Foundation

Parker-Hannifin Corporation

Andrew Sylvester

Gino Banco

Joseph Foss

Paul Resendes

Anand Ramamurthi

Balakrishnan Sivaraman

A multiple-bore solute cartridge carrier) for use in a sterile fluid delivery system. The carrier includes a rotary housing () adapted for connection to the sterile fluid delivery system. The rotary housing has one or more bores () configured to receive a solute cartridge. The rotary housing, when connected to the sterile fluid delivery system, is selectively rotatable to facilitate creation of a desired sterile solution when sterile water from the fluid delivery system is flowed through the solute cartridge.

Multiple-bore solute cartridge carrier

Fibrinolytic nanoparticles including a polymeric core having a surface that is functionalized with a cationic amphiphilic compound, and a fibrinolytic agent dispersed within the core, are described herein. The fibrinolytic nanoparticles can be used in method of dissolving a blood clot in a subject by administering to the subject a therapeutically effective amount of fibrinolytic nanoparticles.

Nanoparticles for controlled lysis of blood clots

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Cleveland, OH, United States of America

Andrew Sylvester