Pharmacopeia Inc.

Msd Oss B.v.

Merck Sharp + Dohme B.v.

N.v. Organon

Andrew Stanley Edwards

David Jonathan Bennett

Koc-Kan Ho

Michael H Ohlmeyer

Nasrin Ansari

Andrew John Cooke

Michelle Lee Morris

Irina Neagu

Yajing Rong

Jui-Hsiang Chan

Emma Louise Carswell

Andrew Roughton

Andrew Cooke

Andrew Laird Roughton

Olaf Nimz

Fiona Elizabeth Andrews

The present invention relates to 1-(4-ureidobenzoyl)piperazine derivatives having the general Formula I (We bring to your attention that formula I is not provided on this electronic version as it is provided in the abstract of the paper copy) Wherein Ris (C)alkyl, (C)cycloalkyl or (C)cycloalkyl(C)alkyl, each of which may be substituted by hydroxy, cyano or halogen; Rrepresents 1 or 2 optional halogens; Ris (C)alkyl, (C)cycloalkyl or (C)cycloalkyl(C)alkyl, each of which may be substituted by one or more halogens; A represents a heteroaryl ring system comprising 1-3 heteroatoms selected from N, O and S, which ring system is 5- or 6-membered when X is C, and 5-membered when X is N; n is 1 or 2; or a pharmaceutically acceptable salt thereof; to pharmaceutical compositions comprising the same, and to the use of a these 1-(4-ureidobenzoyl)piperazine derivatives for the manufacture of a medicament for treating or preventing atherosclerosis and related disorders associated with cholesterol and bile acids transport and metabolism. 

1-(4-ureidobenzoyl)piperazine derivatives

The present invention relates to hexafluoroisopropanol derivatives having the general formula I to pharmaceutical compositions comprising the same and to the use of these hexafluoroisopropanol derivatives in the treatment of atherosclerosis.

Hexafluoroisopropanol derivatives

The present invention relates to N-benzyl,N'-arylcarbonylpiperazine derivatives having the general formula I to pharmaceutical compositions comprising the same, and to the use of a these N-benzyl,N&#x2032;-arylcarbonylpiperazine derivatives for the manufacture of a medicament for treating or preventing atherosclerosis and related disorders associated with cholesterol and bile acids transport and metabolism.

N-benzyl,N'-arylcarbonylpiperazine derivatives

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Newhouse, United Kingdom

Andrew Stanley Edwards