General Electric Company

Andrew Soliz Torres

Vasile Bogdan Neculaes

Antonio Caiafa

Allen Lawrence Garner

Matthew David Butts

Peter John Bonitatibus, Jr

Robert Edgar Colborn

Amit Mohan Kulkarni

Bruce Allan Hay

Brian Christopher Bales

Binil Itty Ipe Kandapallil

Brian Duh-Lan Lee

Jason William Castle

Jeannette Christine Roberts

Brian Dun-Lan Lee

Scott Charles Evans

Juan J Becerra

John Richard Nelson

Stephen Francis Bush

Amit Kulkarni

Paul William Buckley

Oskar Axelsson

Michael Ernest Marino

Christine Angela Morton

Steve Lambert Klopman

Brian Michael Davis

Faisal Ahmed Syud

Thomas Stephen Markham

Ying Zhou

Nichole Lea Wood

Daniel Eugene Meyer

David Cheney deMoulpied

Nicole Evelyn LaPlante

Ming Zhao

Chiaki Treynor

Michacl Ernest Marino

Juan Jose Becerra

Peter John Bonitatibus Jr

Brian C Bales

Peter John Jnr Bonitatibus

David Demoulpied

Jr Peter Bonitatibus

Methods and systems for releasing growth factors are disclosed. In certain embodiments, a blood sample is exposed to a sequence of one or more electric pulses to trigger release of a growth factor in the sample. In certain embodiments, the growth factor release is not accompanied by clotting within the blood sample.

Platelet activation and growth factor release using electric pulses

The present disclosure relates to the generation of an activated platelet product in which one or more of the presence or absence of clots, the timing of clot formation (if present), and/or the mechanical strength of clots (if present) is controlled by the presence or concentration of calcium ions during the activation process. In certain embodiments, the calcium ion concentration is controlled in the presence of pulsed electric fields or a chemical activator (e.g., thrombin) as part of the activation process.

Calcium controlled activation of platelets via electrical stimulation

In accordance with the present disclosure, exposure of a sample to one or more electric pulses via capacitive coupling is described. In certain embodiments, the sample may be a biological sample to be treated or modified using the pulsed electric fields. In certain embodiments, the electric pulses may be delivered to a load using capacitive coupling. In other embodiments, the electric pulses may be bipolar pulses.

Electric pulse generation system using capacitive coupling

The present disclosure relates to a composition of albumin microbubbles to which are bound one or more moieties that exhibit a binding preference for the albumin microbubbles relative to free, native HSA. Production of the albumin microbubble composition and use of the albumin microbubble composition in ultrasound mediated delivery of therapeutic or diagnostic agents is also discussed.

Microbubble tether for diagnostic and therapeutic applications

Methods and systems for generating a tunable or customizable activated product composition are related. In certain embodiments, one or more of electric pulse parameters, flow rate, or sample container size are varied so as to generate the activated product composition. The activated product composition may be customized or optimized based for a particular patient or procedure.

Activated platelet composition with tunable growth factor level

Electric pulse generation systems using capacitive coupling

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Niskayuna, NY, United States of America

Andrew Soliz Torres