Amgen Inc.

Andrew Smith

Sarah Elizabeth Lively

Jay Patrick Powers

Juan Carlos Jaen

Daqing Sun

Timothy David Cushing

Dustin L McMinn

David John Kopecky

Xiaolin Hao

Marc Labelle

Zhulun Wang

Youngsook Shin

Mario G Cardozo

Christopher Neil Farthing

Michael R Degraffenreid

Marie-Louise Smith

Alexander David Frenkel

Craig Tomooka

Simon A Burkitt

Sven P Rasmussen

Xian Yun Jiao

XianYun Jiao

Compounds, compositions and methods that are useful in the treatment of inflammatory, immunoregulatory, metabolic, infectious and cell proliferative diseases or conditions are provided herein. In particular, the invention provides compounds which modulate the expression and/or function of proteins involved in inflammation, metabolism, infection and cell proliferation. The subject compounds contain a fused heterobicyclic ring.

Antiinflammation agents

Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment of inflammatory and immune-related conditions or disorders. In particular, the invention provides compounds which modulate the expression and/or function of proteins involved in inflammation, immune response regulation and cell proliferation. The subject compounds are 2-amino-imidazole derivatives.

Benzimidazole derivatives

Growing community of inventors

Macclesfield, United Kingdom

Andrew Smith