Pfizer Corporation

Andrew Simon Cook

Andrew Douglas Baxter

David Hepworth

Charlotte Moira Norfor Allerton

Stephen Kwok-Fung Wong

Donald Stuart Middleton

Alan Stobie

David Cameron Pryde

Adam Gillmore

Stephen Challenger

Jingrong Jean Cui

Cynthia Louise Palmer

Mark Edward Bunnage

Kevin Neil Dack

Judith Gail Deal

Patrick Stephen Johnson

Ted William Johnson

Hong Shen

Mingying He

Phuong Thi Quy Le

Danlin Gu

Kevin Nell Dack

Phuong Thi Le

Charlotte Moira Allerton

The invention relates to compounds of Formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the present invention are useful in numerous diseases in which ALK protein is involved or in which inhibition of ALK activity may induce benefit, especially for the treatment of cancer mediated by a mutated EML4-ALK fusion protein. 

Alkoxy-substituted 2-aminopyridines as ALK inhibitors

The present invention provides for compounds of formula (I), (Ia) and (Ib) Wherein:

Morpholine dopamine agonists

Compounds of formula (I), (Ia) and (Ib) useful as a medicament.

The invention relates to compounds of formula (I) for treating for example sexual dysfunction, wherein Ris optionally substituted Calkyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, hydrogen, Calkoxy, &#x2014;NRRor &#x2014;NRSOR; X is the linkage &#x2014;(CH)&#x2014; or &#x2014;(CH)&#x2014;O&#x2014; (wherein Y is attached to the oxygen); wherein one or more hydrogen atoms in linkage X may be replaced independently by Calkoxy; hydroxy; hydroxy(Calkyl); Ccycloalkyl; carbocyclyl; heterocyclyl; or by Calkyl optionally substituted by one or more fluoro or phenyl groups; n is 3, 4, 5, 6 or 7; and q is 2, 3, 4, 5 or 6; and Y is phenyl or pyridyl, each of which may be substituted; or two Rgroups on adjacent carbon atoms together with the interconnecting carbon atoms may form a fused optionally substituted 5- or 6-membered carbocyclic or heterocyclyic ring.

N-phenpropylcyclopentyl-substituted glutaramide derivatives as inhibitors of neutral endopeptidase

The invention relates to compounds of formula (I) for treating for example sexual dysfunction, wherein R is optionally substituted C alkyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, hydrogen, C alkoxy, &mdash;NR R or &mdash;NR SO R ; X is the linkage &mdash;(CH ) &mdash; or &mdash;(CH ) &mdash;O&mdash; (wherein Y is attached to the oxygen); wherein one or more hydrogen atoms in linkage X may be replaced independently by C alkoxy; hydroxy; hydroxy(C alkyl); C cycloalkyl; carbocyclyl; heterocyclyl; or by C alkyl optionally substituted by one or more fluoro or phenyl groups; n is 3, 4, 5, 6 or 7; and q is 2, 3, 4, 5 or 6; and Y is phenyl or pyridyl, each of which may be substituted; or two R groups on adjacent carbon atoms together with the interconnecting carbon atoms may form a fused optionally substituted 5- or 6-membered carbocyclic or heterocyclyic ring.

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Sandwich, United Kingdom

Andrew Simon Cook