Biosante Pharmaceuticals, Inc.

Cell Genesys, Inc.

University of California

Gbp Ip, LLC

Aduro Gvax Inc.

Andrew Simmons

Karin Ute Jooss

Thomas L Dull

James G McArthur

Jianmin Fang

Dale John Talbot

Ryan McGuinness

Michael Kelly

Lisa V Tsui

Jing-Jing Qian

James Patrick Allison

Jing Jing Qian

Debbie Farson

Cellular compositions and methods for inducing an immune response to tumor cells are described. The cellular compositions include a tumor antigen and cells that have been modified to express a cytokine and one or more of a tumor antigen, anti-CTLA4 antibody and an additional cytokine. The cellular compositions find utility in methods for treating cancer.

Cancer immunotherapy compositions and methods of use

Recombinant lentiviruses and transfer vectors for transgene delivery as well as methods for gene therapy using such vectors are disclosed. The invention provides a third generation lentiviral packaging system and a set of vectors for producing recombinant lentiviruses, as well as novel tissue specific enhancer and promoter elements useful for optimizing liver specific transgene delivery. The transgene is preferably a blood clotting factor such as human factor IX (hFIX) or human factor VIII (hFVIII) and can be used for treatment of hemophilia.

Lentiviral vectors featuring liver specific transcriptional enhancer and methods of using same

Vector constructs for expression of two or more functional proteins or polypeptides under operative control of a single promoter and methods of making and using the same are described. The vectors comprise a self-processing cleavage site between each respective protein or polypeptide coding sequence. The vector constructs include the coding sequence for a self-processing cleavage site and may further include an additional proteolytic cleavage sequence which provides a means to remove the self processing peptide sequence from expressed protein(s) or polypeptide(s). The vector constructs find utility in methods for enhanced production of biologically active proteins and polypeptides in vitro and in vivo.

Compositions and methods for enhanced expression of recombinant polypeptides from a single vector using a peptide cleavage site

Lentivector constructs for expression of recombinant proteins, polypeptides or fragments thereof and methods of making the same are described. The lentivectors typically have a self-processing cleavage sequence between a first and second protein or polypeptide coding sequence allowing for expression of a functional protein or polypeptide under operative control of a single promoter and may further include an additional proteolytic cleavage sequence which provides a means to remove the self-processing cleavage sequence from the expressed protein or polypeptide. The vector constructs find utility in methods relating to enhanced production of biologically active proteins, such as immunoglobulins or fragments thereof in vitro and in vivo.

Methods to express recombinant proteins from lentiviral vectors

Liver specific transcriptional enhancer

Lentiviral vectors encoding clotting factors for gene therapy

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San Mateo, CA, United States of America

Andrew Simmons