Baylor College of Medicine

The University of Texas System

Arizona State University

William Marsh Rice University

Icahn School of Medicine at Mount Sinai

Andrew Sikora

Karen Anderson

Jeffrey Dale Hartgerink

David Leach

Sri Krishna

Simon Young

Falguni Parikh

Jared M Newton

Robin Parihar

Padmini Jayaraman

Marshall Posner

Provided herein are compositions comprising multi domain peptide (MDP) hydrogels where the peptides that constitute the hydrogel have at least one N6-(1-iminoethyl)-lysine side chain. Also provided are hydrogels that further comprise a STING agonist, an immune checkpoint inhibitor, and/or an anti-cancer therapy. Also provided are methods of using such compositions in the treatment of cancer.

Synthetic multidomain peptide biomaterials that inhibit inducible nitric oxide synthase

Embodiments of the present disclosure pertain generally to head and neck squamous cell carcinomas (HNSCCs) related to human papillomavirus subtype 16 (HPV16) infections. More particularly, the present disclosure provides novel immunogenic epitopes from HPV16 E2, E6 and E7 antigens restricted by common human leukocyte antigen (HLA) alleles for the diagnosis and treatment of HNSCC. The HPV16 epitopes identified in the present disclosure can be used in combination with blockade of HPV16+ HNSCC-specific checkpoints for targeted immunotherapy.

Materials and methods relating to immunogenic epitopes from human papillomavirus

Embodiments of the disclosure concern methods and compositions related to cancer therapy using myeloid derived suppressor cells (MDSC) as a solo therapy or an adjunct therapy. The MDSCs are prepared by exposing bone marrow cells or blood cells to one or more compositions that induce their differentiation to MDSCs and also to TGF-&#x3b2;1, and in specific embodiments the exposure to TGF-&#x3b2;1 results in the MDSCs having anti-tumor activity and/or immune stimulatory activity.

Immune stimulatory function and anti-tumor activity of TGF-&#x3b2; primed myeloid derived suppressor cells (MDSC)

Growing community of inventors

Houston, TX, United States of America

Andrew Sikora