Cytosorbents Corporation

Andrew Scheirer

Thomas D Golobish

Vincent J Capponi

Phillip Chan

Wei-Tai Young

Tamaz Guliashvili

Maryann Gruda

Pamela O'Sullivan

Vi Dan

Humayra Begum Ali

Timothy Kovacs

Wei Tai Young

Josh Vichare

The invention concerns biocompatible polymer systems comprising at least one polymer with a plurality of pores, said polymer comprising a sulfonic acid salt functionality designed to adsorb a broad range of protein based toxins from less than 0.5 kDa to 1,000 kDa and positively charged ions including but not limited to potassium.

Multi-functional hemocompatible porous bead sorbent for removing protein based toxins and potassium from biological fluids

The invention concerns biocompatible polymer systems comprising at least one polymer with a plurality of pores, said polymer comprising either polyol or zwitterionic groups designed to adsorb endotoxins and other inflammatory mediator molecules. The inventions are in the field of porous polymeric sorbents, also in the field of broadly reducing endotoxins in blood and blood products that can cause endotoxemia, additionally, in the field of broadly removing endotoxins by perfusion or hemoperfusion.

Use of a hemocompatible porous polymer bead sorbent for removal of endotoxemia-inducing molecules

Multi-functional hemocompatible porous polymer bead sorbent for removing protein based toxins and potassium from biological fluids

This invention discloses methods for reducing physiologic molecules in abnormal levels and/or exogenous toxins in blood from blood by way of an extracorporeal circuit comprising a hollow-fiber filter module and polymer sorbent in combination.

Methods for removal of toxins from blood using an extracorporeal circuit comprised of a hollow-fiber filter module and polymer sorbent in combination

Disclosed herein are compositions and methods for preventing or treating acute or chronic oral mucositis, esophagitis, enteritis, colitis, or gastrointestinal acute radiation syndrome (GI-ARS) caused by radiation exposure, using one or more enteron sorbent polymers administered gastrointestinally (e.g. orally, via feeding or gastric tube, via ostomy, or rectally).

Use of gastrointestinally administered porous enteron sorbent polymers to prevent or treat radiation induced mucositis, esophagitis, enteritis, colitis, and gastrointestinal acute radiation syndrome

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Bethlehem, PA, United States of America

Andrew Scheirer