Corium International, Inc.

Andrew Richard Klemm

Parminder Singh

Guohua Chen

Joseph Creagan Trautman

Steven Richard Klemm

Robert Wade Worsham

Danny Lee Bowers

Danir F Bayramov

Esi Ghartey-Tagoe

Janet Wendorf

Steve Williams

Danir Bayamov

In an aspect of the invention, an array of microprotrusions is formed by providing a mold with cavities corresponding to the negative of the microprotrusions, casting atop the mold a first solution comprising a biocompatible material and a solvent, removing the solvent, casting a second solution atop the first cast solution, removing the solvent from the second solution, and demolding the resulting array from the mold. The first solution preferably contains an active ingredient.

Solvent-cast microprotrusion arrays containing active ingredient

A microprojection array is provided, comprising an approximately planar base and a plurality of microprojections, wherein the array comprises a vaccine and a polymeric material. The array may have multiple layers. The vaccine may be placed in only one layer. In another embodiment of the invention, a method of preventing a disease is provided, comprising insertion into the skin of a patient an array of microprojections comprising a layer which comprises a vaccine for that disease and a polymer.

Method of vaccine delivery via microneedle arrays

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Ada, MI, United States of America

Andrew Richard Klemm