Other

Tesaro, Inc.

Merck Sharp + Dohme B.v.

Andrew R Ferguson

Jing Wang

Dmitri Bobilev

Bruce Dezube

Peng Sun

Kristen Anne McEachern

The present invention provides methods of treatment for recurrent cancer(s) through combination therapy with an agent that inhibits programmed death-1 protein (PD-1) signaling and an agent that inhibits poly [ADP-ribose] polymerase (PARP) signaling.

Combination therapies for treating cancer

The present disclosure provides methods of administering certain TIM-3 binding agents to patients having cancer. Dosage regimens for compositions comprising a TIM-3 binding agent are also explicitly provided.

Methods of treating cancer with anti-TIM-3 antibodies

A mobile apparatus has a first articulating section comprising a leading traction control assembly including multiple points of contact inclined at a forward angle, and a second articulating section comprising an intermediate traction control assembly. A propulsion system is configured to coordinate movement of the leading traction control assembly and the intermediate traction control assembly. A connector operatively couples the first articulating section to the second articulating section, and the first articulating section is configured to articulate relative to the second articulating section in response to one or more of the multiple points of contact of the leading traction control assembly coming into contact with an obstacle. A bias assembly is configured to exert a continuous compression force against one or both of the first articulating section and the second articulating section to maximize the number of points of contact between the mobile apparatus and the obstacle.

Mobile reconnaissance apparatus with articulating traction control

Growing community of inventors

Waltham, MA, United States of America

Andrew R Ferguson