Bristol-Myers Squibb Compnay

Andrew Quoc Viet

Nicholas Ronald Wurtz

Andrew K Dilger

Ellen K Kick

Kumar Balashanmuga Pabbisetty

Scott A Shaw

James A Johnson

Zulan Pi

Pravin Sudhakar Shirude

Sutjano Jusuf

Meriah Neissel Valente

Benjamin P Vokits

The disclosure relates to compounds of formula (I), which are formyl peptide 2 (FPR2) receptor agonists and/or formyl peptide 1 (FPR1) receptor agonists. The disclosure also provides compositions and methods of using the compounds, for example, for the treatment of atherosclerosis, heart failure, and related diseases.

Pyrrolidinone derivatives as formyl peptide 2 receptor agonists

The disclosure relates to compounds of formula (I), which are formyl peptide 2 (FPR2) receptor agonists and/or formyl peptide 1 (FPR1) receptor agonists. The disclosure also provides compositions and methods of using the compounds, for example, for the treatment of atherosclerosis, heart failure, chronic obstructive pulmonary disease (COPD), and related diseases. 

Piperidinone formyl peptide 2 receptor and formyl peptide 1 receptor agonists

The present invention provides compounds of Formula (I): wherein A, X and Y are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are myeloperoxidase (MPO) inhibitors and/or eosinophil peroxidase (EPX) inhibitors, which may be used as medicaments.

Thioether triazolopyridine and triazolopyrimidine inhibitors of myeloperoxidase

The present invention provides compounds of Formula (I): wherein A, Y and Rare each as defined in the specification, and compositions comprising any of such novel compounds. These compounds are myeloperoxidase (MPO) inhibitors and/or eosinophil peroxidase (EPX) inhibitors, which may be used as medicaments. 

Triazolopyridine inhibitors of myeloperoxidase

The present invention provides compounds of Formula (I): wherein A and Rare each as defined in the specification, and compositions comprising any of such novel compounds. These compounds are myeloperoxidase (MPO) inhibitors and/or eosinophil peroxidase (EPX) inhibitors, which may be used as medicaments. 

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Schwenksville, PA, United States of America

Andrew Quoc Viet