Ucb Pharma, S.a.

Ucb Celltech

Celltech Chiroscience Limited

Andrew Paul Chapman

David J King

Andrew George Popplewell

Derek Thomas Brown

Andrew Neil Charles Weir

Diljeet Singh Athwal

David John King

David Paul Humphreys

Martyn Kim Robinson

Mariangela Spitali

Dilijeet Singh Athwal

Divalent antibody fragments are described, each of which has one or more interchain bridges containing a synthetic or naturally occurring polymer selected from a polyalkylene, polyakenylene, polyoxyalkylene or polysaccharide. Each bridge may be the residue of a homo- or heterobifunctional cross-linking reagent and serves to link two heavy chains in each antibody fragment via the sulphur atoms of cysteine residues present in the chains. Each fragment may be attached to one or more effector or reporter molecules, and is of use in therapy or diagnostics where it has markedly improved binding and/or pharmacokinetic properties when compared to other antibody fragments which have the same number and type of polymer molecules but in which the polymer molecules are randomly attached.

Divalent antibody fragments

There is disclosed antibody molecules containing at least one CDR derived from a mouse monoclonal antibody having specificity for human TNF&#x3b1;. There is also disclosed a CDR grafted antibody wherein at least one of the CDRs is a hybrid CDR. Further disclosed are DNA sequences encoding the chains of the antibody molecules, vectors, transformed host cells and uses of the antibody molecules in the treatment of diseases mediated by TNF&#x3b1;.

Antibody molecules specific to human tumour necrosis factor alpha

The present invention provides anhost cell expressing a recombinant antibody characterized in that thehost cell has been genetically modified in order to change at least one physical property of one or moreproteins which in the wild type copurify with said recombinant antibody.

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Antibody molecules specific to human tumor necrosis factor alpha

Production of humanised antibodies to TNF&#x3b1;

Biological products

Growing community of inventors

Hampton, United Kingdom

Andrew Paul Chapman