University of Houston System

Andrew Paterson

Richard Coale Willson

Jakoah Brgoch

Erin Finley

Disclosed are methods of detecting one or more analytes in a sample by: (1) associating the sample with a surface that includes an analyte binding agent to result in the immobilization of the analytes on the surface; (2) contacting the analyte with a composition that includes at least one phosphor compound with an affinity for the analyte; (3) formation of immobilized analyte binding agent-analyte-phosphor complexes on the surface; (4) separating unbound phosphor compounds from the immobilized complexes; (5) detecting a presence or absence of a luminescence signal from the immobilized complexes; and (6) correlating the luminescence signal to the presence or absence of the analyte in the sample. The phosphor compound may include (SrBa)MgSiO:EuDy, (SrBa)MgSiO:EuDy, (SrBa)MgSiO:EuDy, (SrBa)MgSiO:Eu, and combinations thereof. Additional phosphor compounds may also be utilized, such as [AE]MgSiO:Eu, [AE]AlO:Eu, Dy, and combinations thereof, where AE is at least one of Ca, Sr, or Ba.

Blue emitting persistent phosphor compositions as diagnostic reporters

In some embodiments, the present disclosure pertains to new compositions of matter that comprise phosphorescent reporters. In some embodiments, the phosphorescent reporters of the present disclosure comprise strontium aluminate. In some embodiments, the strontium aluminate is doped with europium and dysprosium (SrAlO:Eu, Dy). Additional embodiments of the present disclosure pertain to methods of making the aforementioned phosphorescent reporters. In some embodiments, the method includes size reduction of inorganic phosphorescent powders through a combination of wet milling and settling. In additional embodiments, the present disclosure pertains to methods of detecting the phosphorescent reporters in various settings, such as diagnostic settings.

Growing community of inventors

Fremont, CA, United States of America

Andrew Paterson