Ionian Technologies, Inc.

Nat Diagnostics, Inc.

Orthosensor Inc.

Rain Bird Corporation

Dna Sciences, Inc.

Andrew P Miller

Jeffrey G Mandell

Richard B Roth

Honghua Zhang

Jason Addink

Rebecca C Holmberg

Jarrod Provins

Brian K Maples

Marc T Stein

Andrew Chase

Samuel C Walker

David Charles Belongia

Andrew U Chase

The technology relates in part to methods and compositions for isothermal amplification of nucleic acids.

Isothermal amplification components and processes

A specialty nozzle is provided having a pattern adjustment valve that may be adjusted to irrigate a substantially rectangular irrigation area. The nozzle may be further adjusted to irrigate three different substantially rectangular irrigation areas. The nozzle is adjustable to function as a left strip nozzle, right strip nozzle, and side strip nozzle. The strip irrigation setting may be selected by pressing down and rotating a deflector to directly actuate the valve. The nozzle may also include a flow reduction valve to set the size of the rectangular irrigation areas and may be adjusted by actuation of an outer wall of the nozzle. Other specialty nozzles are provided having a fixed pattern template to irrigate a rectangular area, such as left strip, right strip, or side strip.

Rotary strip nozzles

The invention is in general directed to the rapid exponential amplification of short DNA or RNA sequences at a constant temperature.

Nicking and extension amplification reaction for the exponential amplification of nucleic acids

At least one embodiment is directed to an insert for measuring a parameter of the muscular-skeletal system. The insert can be temporary or permanent. In one embodiment, the insert is prosthetic component for a single compartment of the knee. The insert comprises a support structure and a support structure respectively having an articular surface and a load bearing surface. The height of the insert is less than 10 millimeters. At least one internal cavity is formed when support structures are coupled together for housing electronic circuitry, sensors, and the power source. The cavity can be sterilized through a port. A membrane is between the port and the cavity. A sterilization gas permeates the membrane for sterilizing cavity. The membrane reduces the ingress of solids and liquids to the cavity.

Small form factor muscular-skeletal parameter measurement system

At least one embodiment is directed to an insert for measuring a parameter of the muscular-skeletal system. The insert can be temporary or permanent. In one embodiment, the insert is prosthetic component for a single compartment of the knee. The insert comprises a support structure and a support structure respectively having an articular surface and a load bearing surface. The height of the insert can be less than 10 millimeters. At least one internal cavity is formed when support structures are coupled together for housing electronic circuitry, sensors, and the power source. The insert includes a flexible articular surface. Flexible articular surface transfers loading to sensors internal to the insert.

Flexible surface parameter measurement system for the muscular-skeletal system

At least one embodiment is directed to an insert for measuring a parameter of the muscular-skeletal system. The insert can be temporary or permanent. In one embodiment, the insert is prosthetic component for a single compartment of the knee. The insert comprises a support structure and a support structure respectively having an articular surface and a load bearing surface. The height of the insert is less than 10 millimeters. At least one internal cavity is formed when support structures are coupled together for housing electronic circuitry, sensors, and the power source. The internal cavity is isolated from the external environment and can be hermetically sealed. The exterior surfaces of the support structure and the support structure are sterilized.

Orthopedic insert measuring system having a sealed cavity

At least one embodiment is directed to an insert for measuring a parameter of the muscular-skeletal system. The insert can be temporary or permanent. In one embodiment, the insert is prosthetic component for a single compartment of the knee. The insert comprises a support structure and a support structure respectively having an articular surface and a load bearing surface. The height of the insert is less than 10 millimeters. At least one internal cavity is formed when support structures are coupled together for housing electronic circuitry, sensors, and the power source. The cavity is sterilized through a port. A membrane is between the port and the cavity. A sterilization gas permeates the membrane for sterilizing cavity. The membrane prevents ingress of solids and liquids to the cavity.

Growing community of inventors

San Diego, CA, United States of America

Andrew P Miller