Harvard College

Other

Imperial Cancer Research Technology, Ltd.

Imperial Cancer Research Technology Institute

Andrew P McMahon

Clifford J Tabin

Philip W Ingham

David A Bumcrot

Pao-Tien Chuang

Elisa Marti-Gorostiza

Valeria Marigo

Yu Albert Wang

Martin E Lee

Matthew Strecker Burriesci

Lawrence D Wong

Bo Han

Carmen Pepicelli

Erin Culek

Paula Lewis

Andrea M Vortkamp

Seppo Vaino

Brian A Parr

A method and system for making financial or medical decisions. The method comprises training sets of models using classification training with sets of data derived from segregated data sources. Overall weighting of each model within the sets of models are determined for each of the sub-datasets. The sets of models, the overall weighting of each model and a number of examples provided from the data for each of the datasets are transmitted to a central server over a communication network, wherein the central server is configured to determine the relative weights of each of the sets of models in the overall ensemble model based on the number of examples, combine the sets of models, receive new application data, and predict at least one of outcome variables, an uncertainty factor for the variables, and drivers of the outcome variables based on the new application data.

Method and system for generating and aggregating models based on disparate data from insurance, financial services, and public industries

The present invention identifies a method for investigating the response of a cell membrane-associated protein in a living cell to a drug by labeling the protein with a visual marker, and also selectively labeling the membrane portion of the protein with another visual marker, such that upon exposure of the cell to a stimulus, the translocation of the cell membrane-associated protein may be observed directly.

System for screening agonists/antagonists of cellular signaling pathways

The present invention concerns the discovery that proteins encoded by a family of vertebrate genes, termed here hedgehog-related genes, comprise morphogenic signals produced by embryonic patterning centers, and are involved in the formation of ordered spatial arrangements of differentiated tissues in vertebrates. The present invention makes available compositions and methods that can be utilized, for example to generate and/or maintain an array of different vertebrate tissue both in vitro and in vivo.

Hedgehog antibodies

Vertebrate embryonic pattern-inducing proteins, and uses related thereto

The present application relates to a method for modulating the growth state of an lung tissue, or a cell thereof, e.g., by ectopically contacting the tissue, in vitro or in vivo, with a hedgehog therapeutic, a ptc therapeutic, or an FGF-10 therapeutic in an amount effective to alter the rate (promote or inhibit) of proliferation of cells in the lung tissue, e.g., relative to the absence of administration of the hedgehog therapeutic or ptc therapeutic. The subject method can be used, for example, to modulate the growth state of epithelial and/or mesenchymal cells of a lung tissue, such as may be useful as part of a regimen for prevention of a disease state, or in the treatment of an existing disease state or other damage to the lung tissue.

Regulation of lung tissue by patched therapeutics and formulations and uses related thereto

The present invention concerns the discovery of a new family of hedgehog binding proteins, referred to herein as 'hedgehog interacting proteins' or 'HIPs', which are demonstrated to bind to hedgehog polypeptides with high affinity. As described herein, the vertebrate HIP proteins exhibit spatially and temporally restricted expression domains indicative of important roles in hedgehog-mediated induction.

Hedgehog interacting proteins and uses related thereto

Vertebrate embryonic pattern-inducing proteins and uses related thereto

The present invention concerns the discovery of a new family of hedgehog binding proteins, refered to herein as 'hedgehog interacting proteins' or 'HIPs', which are demonstrated to bind to hedgehog polypeptides with high affinity. As described herein, the vertebrate HIP proteins exhibit spatially and temporally restricted expression domains indicative of important roles in hedgehog-mediated induction.

Screening assays for agonists and antagonists of the hedgehog signaling pathway

The present application is directed to the discovery that hedgehog proteins, and agents which effect the activities thereof, can be used to control the formation and/or maintenance of cartilage and bone.

Methods and compositions for regulating skeletogenic formation

The present invention concerns the discovery that proteins encoded by a family of vertebrate genes, termed here hedgehog-related genes, comprise morphogenic signals produced by tissue patterning centers, and are involved in the formation of ordered spatial arrangements of differentiated tissues in vertebrates. The present invention makes available compositions and methods that can be utilized, for example to generate and/or maintain an array of different vertebrate tissue both in vitro and in vivo.

Nucleic acids encoding hedgehog proteins

Compositions comprising hedgehog proteins

Method of promoting chondrocyte differentiation with hedgehog related polypeptides

The present invention concerns the discovery that proteins encoded by a family of vertebrate genes, termed here hedgehog-related genes, comprise morphogenic signals produced by tissue patterning centers, and are involved in the formation of ordered spatial arrangements of differentiated tissues in vertebrates. The present invention makes available compositions and methods that can be utilized, for example to generate and/or maintain an array of different vetebrate tissue both in vitro and in vivo.

Growing community of inventors

Lexington, MA, United States of America

Andrew P McMahon