Amgen Sf, LLC

Amgen Inc.

Andrew P Marcus

Julio Cesar Medina

Michael G Johnson

An-Rong Li

Jiwen Liu

Xiaohui Du

Xiaoqi Chen

Jeffrey Thomas Mihalic

Zice Fu

Jason A Duquette

Jeffrey Deignan

Darin J Gustin

Philippe Bergeron

Liusheng Zhu

Alan X Huang

Compounds are provided having the formula: wherein variables R, R, R, R, R, A, A, L, Q, X and subscript n as described herein. The subject compounds are useful for treatment of inflammatory and immune conditions and diseases. Compositions and methods of treatment using the subject compounds are also provided. For example, the subject methods are useful for treatment of inflammatory and immune disorders and disease such as multiple sclerosis, rheumatoid arthritis, psoriasis, and inflammatory bowel disease.

Compounds, compositions and methods for prevention and treatment of inflammatory and immunoregulatory disorders and diseases

Compounds are provided having the formula: wherein variables A, A, A, A, R, R, R, R, Q and L are as described herein. The subject compounds are useful for treatment of inflammatory and immune conditions and diseases. Compositions and methods of treatment using the subject compounds are also provided. For example, the subject methods are useful for treatment of inflammatory and immune disorders and disease such as multiple sclerosis, rheumatoid arthritis, psoriasis, and inflammatory bowel disease.

[object Object]

Compounds are provided having the formula: wherein variables R, R, R, R, R, Q, L and subscript n are as described herein. The subject compounds are useful for treatment of infammatory and immune conditions and diseases. Compositions and methods of treatment using the subject compounds are also provided. For example, the subject methods are useful for treatment of inflammatory and immune disorders and disease such as multiple sclerosis, rheumatoid arthritis, psoriasis, and inflammatory bowel disease.

Imidazolo-related compounds, compositions and methods for their use

Compounds, compositions and methods that are useful in the treatment of inflammatory and immune conditions and diseases are provided herein. In particular, the invention provides compounds which modulate the expression and/or function of a chemokine receptor. The subject methods are useful for the treatment of inflammatory and immunoregulatory disorders and diseases, such as multiple sclerosis, rheumatoid arthritis and type I diabetes.

CXCR3 antagonists

Compounds are provided that have the formula: where X, A, R, R, R, R, R, R, L and Q are as described herein. These compounds are useful, for example, as modulators of a chemokine receptor and for treatment of inflammatory and immunoregulatory disorders and diseases. Pharmaceutical compositions and methods of using these compounds for the treatment of inflammatory and immunoregulatory disorders and diseases, such as multiple sclerosis, rheumatoid arthritis and type I diabetes, are also provided.

Substituted Quinazolin-4(3H)-one compounds, compositions, and methods for their use

Growing community of inventors

Berkeley, CA, United States of America

Andrew P Marcus