Cardiac Pacemakers, Inc.

Andrew P Kramer

Jeffrey E Stahmann

Imad Libbus

Julio Cesar Spinelli

Jiang Ding

Yinghong Yu

Joseph M Pastore

Rodney W Salo

William J Linder

Rene H Wentkowski

Jesse W Hartley

Tamara Colette Baynham

Julia Moffitt

Qingsheng Zhu

James Kalgren

Anthony V Caparso

Kenneth L Baker

Bruce H KenKnight

Allan Charles Shuros

Gerrard Merrill Carlson

David L Perschbacher

James O Gilkerson

Scott R Vanderlinde

Veerichetty A Kadhiresan

Richard N Cornelussen

Frits W Prinzen

Jihong Qu

Hugh Calkins

Lorenzo A DiCarlo

Ward Y R Vanagt

Jason J Hamann

Kristofer J James

Jeffrey Ross

David B Krig

Lawrence S Baumann

David J Ternes

Gary Thomas Seim

Etienne Huvelle

Albert Maarse

Stephen B Ruble

Paul Allan Haefner

Doug M Birkholz

Weiying Zhao

Ankur Garg

Angelo Auricchio

Jeff E Stahmann

Zhengnian Tang

Krzysztof Z Siejko

M Jason Brooke

Alok S Sathaye

Shelley Marie Cazares

Yousufali H Dalal

William C Lincoln

James Cawthra

Lizbeth M Mino

Ward YR Vanagt

Various aspects of the present subject matter relate to an implantable device. Various device embodiments comprise at least one port to connect to at least one lead with at least electrode, stimulation circuitry connected to the at least one port and adapted to provide at least one neural stimulation therapy to at least one neural stimulation target using the at least one electrode, sensing circuitry connected to the at least one port and adapted to provide a sensed signal, and a controller connected to the stimulation circuitry to provide the at least one neural stimulation therapy and to the sensing circuitry to receive the sensed signal. In response to a triggering event, the controller is adapted to switch between at least two modes. Other aspects and embodiments are provided herein.

Implantable neural stimulator with mode switching

According to an embodiment of a method for providing neural stimulation, activity is sensed, and neural stimulation is automatically controlled based on the sensed activity. An embodiment determines periods of rest and periods of exercise using the sensed activity, and applies neural stimulation during rest and withdrawing neural stimulation during exercise. Other embodiments are provided herein.

System for providing stimulation pattern to modulate neural activity

An embodiment relates to a method for delivering a vagal stimulation therapy to a vagus nerve, including delivering a neural stimulation signal to non-selectively stimulate both afferent axons and efferent axons in the vagus nerve according to a predetermined schedule for the vagal stimulation therapy, and selecting a value for at least one parameter for the predetermined schedule for the vagal stimulation therapy to control the neural stimulation therapy to avoid physiological habituation to the vagal stimulation therapy. The parameter(s) include at least one parameter selected from the group of parameters consisting of a predetermined therapy duration parameter for a predetermined therapy period, and a predetermined intermittent neural stimulation parameter associated with on/off timing for the intermittent neural stimulation parameter.

Systems and methods for avoiding neural stimulation habituation

In various method embodiments for operating an implantable neural stimulator to deliver a neural stimulation therapy to an autonomic neural target, the method comprises using the implantable neural stimulator to deliver the neural stimulation therapy to the autonomic neural target, and evaluating an evoked response to the neural stimulation bursts. The neural stimulation therapy includes a plurality of neural stimulation bursts where each neural stimulation burst includes a plurality of neural stimulation pulses and successive neural stimulation bursts are separated by a time without neural stimulation pulses. Evaluating the evoked response includes sensing the evoked response to the neural stimulation bursts where sensing the evoked response includes sensing at least one physiological parameter affected by the neural stimulation bursts, comparing the sensed evoked response against a baseline, and determining if the evoked response substantially returns to the baseline between neural stimulation bursts.

Neural stimulation with transient response between doses

A system for use during revascularization includes a catheter having an adjustable balloon for delivery a stent, one or more pacing electrodes for delivering one or more pacing pulses to a patient's heart, and a pacemaker configured to generate the one or more pacing pulses to be delivered to the heart via the one or more pacing electrodes. The one or more pacing pulses are delivered at a rate substantially higher than the patient's intrinsic heart rate without being synchronized to the patient's intrinsic cardiac contractions, and are delivered before, during, or after an ischemic event to prevent or reduce cardiac injury.

Method and apparatus for pacing during revascularization

Various aspects of the present subject matter provide a device. In various embodiments, the device comprises a port adapted to connect a lead, a pulse generator connected to the port and adapted to provide a neural stimulation signal to the lead, and a signal processing module connected to the port and adapted to receive and process a nerve traffic signal from the lead into a signal indicative of the nerve traffic. The device includes a controller connected to the pulse generator and the signal processing module. The controller is adapted to implement a stimulation protocol to provide the neural stimulation signal with desired neural stimulation parameters based on the signal indicative of the nerve traffic. Other aspects are provided herein.

System and method for closed-loop neural stimulation

A system embodiment comprises an implantable device including controller circuitry, memory, a transceiver, and a generator configured to generate electrical stimulation to modulate the neural activity. The controller circuitry and the transceiver configured to cooperate to receive, from another device, data corresponding to a user-programmable stimulation pattern and store the data in the memory. The user-programmable pattern includes a programmable pattern of bursts with multiple burst durations and multiple burst interval sequences, and the bursts include pulses with a user-programmable wave morphology. The controller circuitry is operably connected to the memory and the generator to use the data stored in the memory to control generation of the electrical stimulation to provide the user-programmable stimulation pattern that includes the pulses with the user-programmable wave morphology and that includes the multiple burst durations and the multiple burst interval sequences.

Neural stimulation with transient response analysis between doses

A cardiac rhythm management system selects one of multiple electrodes associated with a particular heart chamber based on a relative timing between detection of a depolarization fiducial point at the multiple electrodes, or based on a delay between detection of a depolarization fiducial point at the multiple electrodes and detection of a reference depolarization fiducial point at another electrode associated with the same or a different heart chamber. Subsequent contraction-evoking stimulation therapy is delivered from the selected electrode.

Cardiac rhythm management system selecting between multiple same-chamber electrodes for delivering cardiac therapy

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Marine on St. Croix, MN, United States of America

Andrew P Kramer