Divergence, Inc.

Andrew P Kloek

Deryck Jeremy Williams

Jennifer A Davila-Aponte

Merry B McLaird

Michelle Coutu Hresko

John D Bradley

SiQun Xu

Anita M Frevert

Catherine Baublite

Brandy Salmon

Rodolfo Zentella

Michelle L Verbsky

Brandi J Chiapelli

Ronald E Worthington

Michelle L Gasper

Anita M Frevert-Thompson

Nucleic acid molecules from nematodes encoding phosphoethanolamine n-methyltransferase polypeptides are described. PEAMT-like polypeptide sequences are also provided, as are vectors, host cells, and recombinant methods for production of PEAMT-like nucleotides and polypeptides. Also described are screening methods for identifying inhibitors and/or activators, as well as methods for antibody production.

Nematode phosphoethanolamine N-methyltransferase-like sequences

Nucleic acid molecules from nematodes encoding fatty acid desaturase polypeptides are described. Fatty acid desaturase-like polypeptide sequences are also provided, as are vectors, host cells, and recombinant methods for production of fatty acid desaturase-like nucleotides and polypeptides. Also described are screening methods for identifying inhibitors and/or activators of fatty acid desaturase-like polypeptides, as well as methods for antibody production.

Nematode fatty acid desaturase-like sequences

The present invention provides DNA constructs, transgenic plants containing such constructs, and methods of making the plants. The DNA constructs encode a polypeptide that when expressed results in the production of fatty acid compounds having anthelmintic activity. Transgenic plants expressing such a polypeptide can exhibit enhanced resistance to plant parasitic nematodes, particularly when expressed in vegetative tissues.

Method for screening transgenic plants for anthelmintic activity

The present invention provides a method of screening transgenic plants containing a DNA construct encoding a polypeptide that when expressed in the plant results in the production of fatty acid compounds for anthelmintic activity by contacting the plants with a plurality of nematodes.

Method of screening transgenic plants for anthelmintic activity

The present invention provides DNA constructs, transgenic plants containing such constructs, and methods of making the plants. The DNA constructs encode a polypeptide that when expressed results in the production of fatty acid compounds having anthelmintic activity. Transgenic plants expressing such a polypeptide can exhibit enhanced resistance to plant parasitic nematodes, particularly when expressed in vegetative tissues. Transgenic plants expressing such a polypeptide can also be useful for non-pesticidal industrial uses.

Nucleic acids encoding anthelmintic agents and plants made therefrom

Nucleic acid molecules from nematodes encoding ATP synthase subunit E polypeptides are described. ATP synthase subunit E-like polypeptide sequences are also provided, as are vectors, host cells, and recombinant methods for production of ATP synthase subunit E-like nucleotides and polypeptides. Also described are screening methods for identifying inhibitors and/or activators, as well as methods for antibody production.

Nematode ATP synthase subunit E polypeptide

Transgenic plants having anthelmintic activity and methods of producing them

Methods for identifying compounds that bind to nematode ATP synthase subunit E polypeptide

Disclosed are two nucleic acid molecules fromencoding malate dehydrogenase-like (MDH-like) polypeptides. The MDH-like polypeptide sequences are also provided, as are vectors, host cells, and recombinant methods for production of MDH-like nucleotides and polypeptides. The invention further relates to screening methods for identifying inhibitors and/or activators, as well as methods for antibody production.

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San Francisco, CA, United States of America

Andrew P Kloek