Oriel Therapeutics, Inc.

Bayer Intellectual Property Gmbh

Andrew Murray Gow

Scott Alexander Lewis

Jonathan David Tuckwell

David Stuart Harris

Thomas W Ruckdeschel

Rachel Striebig

Charles A Buckner, Iii

Matthew Allen

James Grant Skakoon

David A Schuelke

Gerald A Thoe

George McGee Perkins

Klaus Urich

Mark Jeffrey Edhouse

Matthias Burg

Greg Beard

Claus-Peter Reisinger

Andreas Kalitzki

Samantha Anne Patterson

Kathryn Anne Louise Farrell

Methods of fabricating and operating dry powder inhalers that include dose disks and airway channel disks with sealant layers, the airway channel disks forming radially-extending discrete, typically dose-specific, airway channels serially forming a portion of the inhalation pathway to deliver dry powder to a user using the inhalers.

Dry powder dose container assemblies and related inhalers

A dry powder inhaler includes a dose container assembly having a dose container disk with opposing upper and lower surfaces, a first row of circumferentially spaced apart dose containers at a first radius and a second row of circumferentially spaced apart dose containers at a second radius. The dose containers have dry powder therein and are sealed via a first flexible sealant over apertures in the upper surface and a second flexible sealant over apertures in the lower surface. A piercing mechanism includes two reciprocating piercers that serially alternate between the two rows of dose containers in the dose container disk. A rotatable ramp disk includes first and second sets of circumferentially spaced-apart ramp elements in staggered, concentric relationship that are configured to move the first and second piercing members between retracted and extended positions.

Dry powder inhalers with dual piercing members and methods of operating same

Methods of operating and fabricating inhalers with airway disks having discrete airway channels

A fluid management system adapted to automatically supply fluid for injection into a patient is disclosed. The fluid management system includes a fluid management device, a fluid transfer system and a fluid injector. The fluid management device serves to store and administrate multi-dose containers. The fluid transfer system connects an outlet of these containers to the injector which withdraws a fluid from the containers via the fluid transfer system and injects the fluid to an administration device at the patient. The fluid management device includes at least one rotating carousel having a vertical axis of rotation, at least two container holders attached to the rotating carousel and adapted to position the container vertically with a septum covered end facing downwards, and a spike holder mounted below the rotating carousel and oriented so the spike holder axially aligns a spike connected to the spike holder with the axis of the container.

Fluid management device having rotating carousel with container holders for vertically positioning a container during automated spiking and injection into patient

Dry powder inhalers are described with an inhaler body defining an enclosed cavity space and at least one of (a) an endless strip having opposing primary surfaces, the strip comprising a plurality of spaced apart blisters or dose containers holding dry powder medicament. The inhaler also has an inhalation exit flow path in the inhaler body in communication with at least one blister or at least one dose container held by the strip in a dispensing position and a piercer configured to release dry powder medicament from the blister or dose container in the dispensing position.

Dry powder inhalers with endless strips and cooperating piercers and related methods

Dry powder inhalers with dual piercing members

Dry powder inhalers include radially-extending discrete, typically dose-specific, airway channels serially forming a portion of the inhalation pathway to deliver dry powder to a user using the inhalers.

Inhalers with airway disks having discrete airway channels and related disks and methods

Dry powder inhalers with rotatable piercing mechanisms facilitate the use of dose container assemblies having dose containers arranged in concentric rows. A piercing mechanism is operably associated with the dose container assembly and is configured to pierce sealants that seal a dose container. The piercing mechanism is rotatable such that it can serially alternate between the two rows of dose containers. The piercing mechanism includes a rotatable drum, an elongate piercing member, and a biasing member operably associated with the piercing member. The rotatable drum has an open end, an opposite closed end, and a cylindrical wall that extends from the closed end and terminates at the open end. The closed end includes an aperture formed therein in a location adjacent to the wall. The elongate piercing member is extended and retracted through the aperture to pierce the sealants of a dose container.

Dry powder inhalers with rotating piercing mechanisms and related devices and methods

Dry powder inhalers with dual piercing members and related devices and methods

Growing community of inventors

Porirua, New Zealand

Andrew Murray Gow