Attomarker Limited

University of Exeter

Andalay Technologies Limited

Andrew Mark Shaw

William Leslie Barnes

Alasdair Dow

Rouslan Vladamir Olkhov

Tim Holdway

Rouslan Vladimir Olkhov

The present invention provides a mouthwash composition comprising a heterogeneous gel, wherein said heterogeneous gel comprises at least two gelling agents and two or more active ingredients, and wherein the composition provides the differential release of the active ingredients over a period of time.

Oral composition

We describe a method of predicting the response of a patient to a medical procedure, the method comprising: inputting acute phase response (APR) biomarker data defining a level of an acute phase response (APR) biomarker in said patient at a succession of biomarker measurement times following said medical procedure, said APR biomarker data defining a biomarker time course representing an evolution over time of said acute phase response; and processing said APR biomarker data to determine a derivative with respect to time of said time course from said APR biomarker data to provide APR time series data; determining a prediction of the response of said patient to said medical procedure from said APR time series data.

Systems and methods for medical data processing and analysis

We describe a system/method for predicting the outcome of a medical procedure on a patient. The system/method uses using complement cascade data representing levels of a set of complement cascade markers in the patient at a succession of peri-operative time intervals, determining deviations from a model of the response to provide a pre-symptomatic prediction of the outcome. In embodiments the complement cascade pathways include the lytic pathway and at least one of the lectin pathway, the classical pathway and the alternative pathway, and the biomarkers include at least C3. The system may include an electroluminescence or plasmon-resonance multianalyte detector to analyze a blood sample from the patient.

This invention relates to a method for the fabrication of photonic biosensor arrays and applications of arrays produced by the method in the biomedical field. A method for the fabrication of a biosensor array for plasmon resonance-based sensing of a plurality of different biological targets simultaneously, the method comprising: (i) providing a transparent substrate; ii) providing seed metallic nanoparticles in the form of a colloid; (iii) depositing said colloid as discrete metallic islands on the transparent substrate, each of said metallic islands comprising a plurality of metallic nanoparticles; (iv) washing the substrate in order to remove unadhered material; (v) developing the substrate in a growth solution, which solution comprises a salt of the same metal which is present in the form of discrete metallic islands on the substrate, a reducing agent, a capping agent and optionally a surfactant; (vi) washing the developed substrate; and (vii) functionalising each of said metallic islands with a different functionalising molecule using a common chemical process to attach said different functionalising molecules to said metallic islands.

Method of fabrication of photonic biosensor arrays

This invention relates to photonic biosensor arrays in particular employing plasmon resonance based sensing, and to methods and apparatus for reading such arrays. A biosensor array for plasmon resonance-based sensing of a plurality of different biological targets simultaneously, the array comprising a transparent substrate having a surface bearing a plurality of assay spots for plasmon resonance sensing, each of said assay spots comprising a discrete metallic island, a said metallic island comprising a plurality of metallic nanoparticles to which are attached functionalizing molecules for binding to a said biological target, different said islands bearing different said functionalizing molecules for binding to different ones of said biological targets, and wherein total internal reflection of light at said surface at a wavelength at or near a said plasmon resonance results in scattering of said light away from said surface, said scattering being modulated by said binding of said biological targets.

Growing community of inventors

Exeter, United Kingdom

Andrew Mark Shaw