Incube Labs, LLC

Andrew Mangogna

Mir A Imran

Timothy John Williams

Glen W McLaughlin

Mir Hashim

Radhika Korupolu

Joel M Harris

Sanjay V Patel

Chang Jin Ong

Lu Wang

Huma Arastu

Rekha Vaidyanathan

Glen Mclaughlin

Sanjay Patel

Various embodiments provide methods and systems for the biphasic iontophoretic transdermal delivery of therapeutic agents. An embodiment of a method for such delivery comprises positioning at least one electrode assembly in electrical communication with a patient's skin. The assembly includes a solution comprising a therapeutic agent which passively diffuses into the skin. A dose of agent is delivered from the assembly into the skin during a first period using a first current having a characteristic e.g., polarity and magnitude, to repel the agent out of the assembly. During a second period, a second current having a characteristic to attract the agent is used to retain the agent in the assembly such that delivery of agent into skin is minimized. A dose of agent may be delivered on demand by an input from the patient. Embodiments may be used for delivery of agents which cause adverse effects from unwanted passive diffusion.

System and method for biphasic transdermal iontophoretic therapeutic agents

System and method for biphasic transdermal iontophoretic delivery of therapeutic agents

System and method for biphasic transdermal iontophreotic delivery of therapeutic agents

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San Jose, CA, United States of America

Andrew Mangogna