Chiron Corporation

Mitokor, Inc.

Andrew Malcolm Bray

Peter G Schultz

David B Ring

Stephen David Harrison

Steven Rosenberg

Kerry L Spear

Robert Valerio

Rudolf Karl Andreas Giger

Timothy Lloyd Belcher

Nobuyoshi Joe Maeji

Henri Mattes

Inhibitors of glycogen synthase 3 kinase

A synthesis member preferably comprises two elements: a crown and a stem. The stem includes a tag, such as a transponder, that is used to identify the synthesis member and/or the synthetic history of the synthesis member when used in the automated synthesis of compound libraries containing large numbers (e.g. 1000 or more) compounds. The crown provides the location at which compounds are synthesized. The combination of a crown for use with compound synthesis and stem allows the tracking of individual synthesis members from a library containing thousands of such synthesis members. Because each synthesis member is individually tracked and can be logged into a database and/or process flow control system, the synthesis of several thousand individual compounds in conventional containers, such as round bottom flasks is made possible using only traditional compound synthesis approaches.

Transponder tagging of constituents used in compound synthesis

Compounds of formula 1: ##STR1## wherein R.sub.1 is alkyl, cycloalkyl, aryl, aralkyl, heteroaryl, or heteroaralkyl, substituted with 0-3 substituents selected from lower alkyl, halo, hydroxy, lower alkoxy, amino, lower alkyl-amino, and nitro; R.sub.2 is hydroxy, amino, or lower alkoxy; R.sub.3 is H, lower alkyl, lower acyl, lower alkoxy-acyl, or amnino-acyl; R.sub.4 is H or lower alkyl; and pharmaceutically acceptable salts and esters thereof; are effective inhibitors of GSK3.

Effective urokinase-type plasminogen activator receptor antagonists have sequences selected from the group LNFGQYLWYT, LCFGCYLWYT, LNFGCYLWCT, LNFGQYLnAYT, LNFdSQYLWYT, LCFGCYLWY, LNFdSQYLnAYT, LNFGdCYLWCT, LCFdSCYLWYT, LCFdSCYLnAYT, LNFdSCYLWCT, or active analogs or active portions thereof.

Peptide analog inhibitors of urokinase receptor activity

The invention relates to a vessel apparatus for holding and transferring liquids, in which the level of liquid may be controlled and monitored automatically. A depth sensing device, included in the apparatus, detects the presence or absence of liquid at predetermined levels. The device detects the difference in transmission of a low frequency electromagnetic signal between aerial probes based on the state of immersion (wet or dry) of the transmitting and receiving probes.

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Victoria, Australia

Andrew Malcolm Bray