Case Western Reserve University

Other

The Cleveland Clinic Foundation

University Hospitals of Cleveland

Olympus Optical Company, Ltd.

Duke University

University of Hospitals of Cleveland

Andrew M Rollins

Joseph A Izatt

Siavash Yazdanfar

Michael W Jenkins

Michael V Sivak

Matthew R Ford

Christine P Fleming

Volker Westphal

David L Wilson

Tadashi Hirata

Akihiro Horii

Shuhei Iizuka

Manish Dinkarrao Kulkarni

William J Dupps

Hiram G Bezerra

Zhao Wang

Rahul Seth

Osman Chughtai

Hui Wang

Xiaoyong Fu

Changhuei Yang

Jonathan Edgar Roth

Michael Choma

Paul K Krakovitz

Brian E Applegate

Jiro Narita

Paul R Krakovitz

Brecken Blackburn

Marco Costa

Shi Gu

Zhilin Hu

Divakar K Rao

B J Dupps

Cameron J Pedersen

Systems, methods, and other embodiments associated with characterizing Radio Frequency Ablation (RFA) lesions using Optica Coherence Tomography (OCT) are described. One example method includes acquiring an OCT signal from a Region Of Interest (ROI) in an ablated material. The example method may also include determining whether a lesion was formed by the ablation by analyzing optical properties of the ROI as recorded in the OCT signal.

Characterizing ablation lesions using optical coherence tomography (OCT)

Systems, methods, and other embodiments associated with characterizing Radio Frequency Ablation (RFA) lesions using Optical Coherence Tomography (OCT) are described. One example method includes acquiring an OCT signal from a Region Of Interest (ROI) in an ablated material. The example method may also include determining whether a lesion was formed by the ablation by analyzing optical properties of the ROI as recorded in the OCT signal.

One example includes a scanning system. The system includes a phase-decorrelation optical coherence tomography (PhD-OCT) scanner configured to implement a scanning sequence via an optical signal on a sample medium. The system also includes a scanning controller configured to provide control signals to the PhD-OCT scanner to implement the scanning sequence and to obtain phase and amplitude information associated with a reflected version of the optical signal. The phase and amplitude information can be indicative of microscale dynamics of the sample medium. The scanning controller can also implement an algorithm to calculate a quantitative parameter of the sample medium based on the phase and amplitude information associated with the sample medium.

Phase-decorrelation optical coherence tomography-based parameter measurement

This disclosure relates to an OCT apparatus configured to generate to electromagnetic (e.g., optical) signals having two different polarization states. Two or more silicon optical amplifiers (SOAs) can be configured to maintain a respective polarization state in an optical input signal provided from a light source (e.g., a broadband light source). The different polarization states can be combined by an optical combiner (e.g., a polarization maintaining fiber coupler) and provided to drive a reference arm and a sample arm implemented in an OCT system.

Polarization sensitive optical coherence tomography using multiple polarization sensitive semiconductor optical amplifiers

A method includes storing three-dimensional image data acquired intravascularly via an optical coherence tomography (OCT) apparatus. The image data is analyzed to compute a probability estimate of stent presence at support positions appearing in an A-line. Stent strut locations are located in three-dimensional space based on the computed probability estimate of stent presence.

Analysis of optical tomography (OCT) images

A device for determining the presence of abnormal fluid in a middle ear of a subject includes an elongated probe, a first light source housed within the elongated probe, and a second light source housed within the elongated probe. The elongated probe includes a distal end for inspection of an ear. The First light source is configured to convey an optical beam through a tympanic membrane associated with the middle ear of the subject, without puncturing the tympanic membrane. The second light source is configured to convey light through the distal end of the elongated probe and illuminate the tympanic membrane.

Device and method for determining the presence of middle ear fluid

Systems and method are provided for evaluating a biomechanical property of tissue. A shear wave generator is configured to induce a shear wave in the tissue. An optical coherence tomography (OCT) imager is configured to capture a B-scan frame of the tissue. An image processing component is configured to determine a frequency of the shear wave in the tissue from the B-scan frame of the tissue at each of a plurality of locations within the B-scan. A parameter calculation component is configured to calculate a value for the biomechanical property for a plural subset of the plurality of locations within the B-scan frame of the tissue from the determined frequency of the shear wave at each of the plural subset of the plurality of locations.

Measurement of biomechanical properties in an OCT image

Systems, methods, and other embodiments associated with gated optical coherence tomography (OCT) are described. One example method includes generating an image control signal to control an OCT apparatus to acquire an image of an embryonic heart at a specified point in time during a cardiac cycle of the embryonic heart. The method may also include controlling the OCT apparatus to acquire the image based on the image control signal. In different examples, the image may be acquired in vivo or from an excised heart that is paced. The OCT apparatus and the embryonic heart may be housed in an environmental chamber having a set of controllable environmental factors. Therefore, the method may include detecting and controlling the set of controllable environmental factors.

Gated optical coherence tomography (OCT)

A system and related methods for automatic or semi-automatic segmentation and quantification of blood vessel structure and physiology, including segmentation and quantification of lumen, guide wire, vessel wall, calcified plaques, fibrous caps, macrophages, metallic and bioresorbable stents are described, and including visualization of results. Calcified plaque segmentation can be used to estimate the distribution of superficial calcification and inform strategies stenting. Volumetric segmentation and quantification of fibrous caps can provide more comprehensive information of the mechanisms behind plaque rupture. Quantification of macrophages can aid diagnosis and prediction of unstable plaque and associated acute coronary events. Automated detection and quantification of metallic and bioresorbable stents can greatly reduce the analysis time and facilitate timely decision making for intervention procedures.

Segmentation and quantification for intravascular optical coherence tomography images

Gated optical coherence tomography (OCT) environmental chamber

Systems and methods are provided for characterizing biomechanical properties of tissue within an eye. A perturbation component introduces a stress to the eye tissue. An imaging component is operative to obtain an image of the eye tissue. A first image of the tissue can be obtained prior to the introduction of the stress and a second image of the tissue can be obtained after the introduction of the stress. An image analysis component compares the first image and the second image as to determine at least one biomechanical property of the tissue.

Method for measuring biomechanical properties in an eye

Growing community of inventors

Highland Heights, OH, United States of America

Andrew M Rollins