Emd Millipore Corporation

Millipore (u.k.) Limited

Andrew Lyddiatt

Nanying Bian

Neil P Soice

Kwok-Shun Cheng

Chen Wang

Joaquin A Umana

Senthilkumar Ramaswamy

Brian Gagnon

Dennis Aquino

Katherine Louise Angus

Gordon R Duffin

Victoria Jane Dolan

Senthikumar Ramaswamy

The present invention provides a new method for isolation and/or purification of immunoglobulins from a solution containing one or more immunoglobulins using a solid phase matrix represented by the formula: M-SP-L, wherein M is designates a matrix backbone, SP designates a spacer and L designates a substituted benzimidazole ligand.

Benzimidazole compounds and their use as chromatographic ligands

The present invention relates to an asymmetric chromatography media suitable for separations applications, particularly as packed bed, fluidized bed or magnetized bed chromatography media. In certain embodiments, the asymmetric chromatography media comprises asymmetric particles, preferably beads, having at least two distinct, controlled pore size distributions. Preferably one of the distinct pore size distributions is in an internal region of the particle, and the other is in an external region or coating on the particle. These distinct pore size distributions can be modified with uniform or alternatively unique functional groups or mixtures of functional groups. The present invention allows for the control over pore size distribution within an asymmetric porous particle by providing a distinct internal region, preferably in the form of a bead, and a distinct external region, preferably in the form of a coating on the bead.

Asymmetric porous adsorptive bead

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Shotley Bridge, United Kingdom

Andrew Lyddiatt