Biocompatibles UK Limited

Abbott Laboratories Corporation

Boston Scientific Medical Device Limited

The United States of America, As Represented by the Secretary, Department of Health and Human Services

Johnson & Johnson Gmbh

Biocompatibles Limited

National Institutes of Health

Andrew Lennard Lewis

Yiqing Tang

Peter William Stratford

Sean Leo Willis

Simon Leppard

Koorosh Ashrafi

Matthew R Dreher

Stéphane Hohn

Michael John Driver

Maria Victoria Fajardo Gonzalez

Pedro Garcia

Brenda Hall

Steven Peter Armes

Richard Paul Redman

Hugh Britton

Laurence Gerald Hughes

Jane Louise Court

Jonathan Vince

Yinghua Ma

Stephen James Brocchini

Antony Robert Godwin

Giuseppe Battaglia

Damien Guegan

Maria Victoria Gonzalez Fajardo

Emma Janice Lobb

Bradford Johns Wood

Stuart Russell

Stephen A Jones

Hans Werner Schoelling

Vincent James O'Byrne

Ayele H Negussie

Richard Neil Templar Freeman

Martyn Christopher Davies

Francesco Cuda

Irene Canton

Anthony Claude Marie Collias

Karin Lochte

Stuart Clarke

Andrew Lloyd

Marzia Massignani

Cristian Parisi

Andris Egle

Gary James Phillips

Jasmine Lord

Damien Guégan

David Michael Grey

Samantha Ryan

Clare Heaysman

Hind Hassan Sidahmed Goreish

Stephen Alister Jones

Vincent James Conor O'BYRNE

Shui Ting Chung

Marcus Gordon Caine

Gary Philips

Maria Victoria Gonzalez-Fajardo

Clare Louise Heaysman

Gary Phillips

Stephane Hohn

Damien GUÉGAN

Richard Edward John Forster

Andrew William Lloyd

This invention relates to radiopaque polymers and to their use, particularly in the manufacture of medical devices and in methods of medical treatment, including therapeutic embolization. In particular embodiments the present disclosure relates to a hydrophilic polymer comprising pendent groups which a phenyl ring is substituted with one or more iodine groups and one or more non-iodine groups as described in more detail herein.

Radiopaque polymers

Disclosed is a signal processing method for a distributed acoustic sensing system (DAS), where a scattered signal that was scattered at a scattering location along an optical path is received and interfered with a local oscillator signal to generate a first carrier signal that is modulated by a phase difference between the local oscillator signal and the scattered signal. The first carrier signal is then digitally processed in order to generate a second carrier signal that is modulated by a spatial differential of the phase difference. The spatial differential of the phase difference is directly related to the strain (or acoustic environment) of the optical path at the scattering location, and so enables the strain at the scattering location to be estimated.

Signal processing methods for an optical detection system

A liquid composition comprising a polymer having pendant groups of the formula I: (I) Wherein X is either a bond or is a linking group having 1 to 8 carbons and optionally 1 to 4 heteroatoms selected from O, N and S; and n is 1 to 4.

A polymer having a backbone comprising a polyhydroxylated polymer cross linked by a C3 to C8 diacid.

Radiopaque hydrogels, in particular radiopaque hydrogel microspheres, comprising a polymer having 1,2-dil or 1,3-diol groups acetalized with radiopaque species.

The present disclosure relates to radiopaque PVA polymers where the PVA has a first pendant group and a second pendant group, wherein the first pendant group comprises a first phenyl group bearing 1 to 5 iodine atoms, and the second pendant group comprises either (a) a second phenyl group bearing 1 to 3 substituents selected from the group W and optionally 1 to 4 iodine substituents, the group(s) W and the optional iodines being the sole substituents of the second phenyl group. Each W is selected from &#x2014;OH, &#x2014;COOH, &#x2014;SOH, &#x2014;OPOH, &#x2014;O&#x2014;(Calkyl), &#x2014;O&#x2014;(Calkyl)OH, &#x2014;O&#x2014;(Calkyl)R, &#x2014;O&#x2014;(CHO)R&#x2014;(C&#x2550;O)&#x2014;O&#x2014;Calkyl and &#x2014;O&#x2014;(C&#x2550;O)Calkyl; wherein Ris H or Calkyl; Ris &#x2014;COOH, &#x2014;SOH, or &#x2014;OPOH; q is an integer from 1 to 4; wherein the group W may be in the form of a pharmaceutically acceptable salt; or (b) a pyridyl group; which is optionally in the form of a pyridinium ion.

A hydrophilic polymer comprising pendent groups of the formula I: Wherein: W is independently selected from &#x2014;OH, &#x2014;COOH, &#x2014;SOH, &#x2014;OPOH, &#x2014;O&#x2014;(Calkyl), &#x2014;O&#x2014;(Calkyl)OH, &#x2014;O&#x2014;(Calkyl)R, &#x2014;O&#x2014;(CHO)R&#x2014;(C&#x2550;O)&#x2014;O&#x2014;Calkyl and &#x2014;O&#x2014;(C&#x2550;O)Calkyl; or a group &#x2014;BZ; wherein &#x2014;OH, COOH, O&#x2014;POH and SOH maybe in the form of a pharmaceutically acceptable salt; wherein: B is a bond, or a straight branched alkanediyl, oxyalkylene, alkylene oxaalkylene, or alkylene (oligooxalkylene) group, optionally containing one or more fluorine substituents; and Z is an ammonium, phosphonium, or sulphonium phosphate or phosphonate ester zwitterionic group; X is either a bond or a linking group having 1 to 8 carbons and optionally 1 to 4 heteroatoms selected from O, N and S; G is a coupling group through which the group of the formula I is coupled to the polymer and is selected from ether, ester, amide, carbonate, carbamate, 1,3 dioxolone, and 1,3 dioxane; Ris H or Calkyl; Ris &#x2014;COOH, &#x2014;SOH, or &#x2014;OPOHq is an integer from 1 to 4; n is an integer from 1 to 4; p is an integer from 1 to 3; and n+p is from 2 to 5; and wherein &#x2014;COOH, &#x2014;OPOHand &#x2014;SOH as well as phenolic &#x2014;OH maybe in the form of a pharmaceutically acceptable salt.

This invention concerns imageable, radiopaque embolic beads, which are particularly useful for monitoring embolization procedures. The beads comprise iodine containing compounds which are covalently incorporated into the polymer network of a preformed hydrogel bead. The beads are prepared by activating pre-formed hydrogel beads towards nucleophilic attack and then covalently attaching iodinated compounds into the polymer network. The radiopaque beads may be loaded with chemotherapeutic agents and used in methods of embolizing hyperplastic tissue or solid tumors.

Imageable embolic microsphere

This invention relates to imageable polymers, particularly those comprising poly vinylalcohol and to methods for making them as well as to embolic microspheres comprising the polymers. The microspheres are imageable during embolization procedures and can be loaded with drugs or other therapeutic agents to provide an imageable drug delivery system.

Imageable polymers

Radiopaque hydrogels, in particular radiopaque hydrogel microspheres, comprising a polymer having 1,2-diol or 1,3-diol groups acetalised with radiopaque species.

Pharmaceutical compositions comprising embolic particles, that optionally comprise pharmaceutical actives, in oil or emulsion formulations that are useful in therapeutic embolization procedures, particularly for the treatment of vascularised neoplasias, such as liver carcinomas.

Oily compositions

Radiopaque hydrogels, in particular radiopaque hydrogel microspheres, comprising a polymer having 1,2-diol or 1,3-diol groups acetalized with radiopaque species.

Growing community of inventors

Surrey, United Kingdom

Andrew Lennard Lewis