Pharmacopeia Inc.

Msd Oss B.v.

N.v. Organon

Merck Sharp + Dohme B.v.

Andrew Laird Roughton

Michael H Ohlmeyer

Yajing Rong

Koc-Kan Ho

Nasrin Ansari

Irina Neagu

Andrew John Cooke

David J Diller

David Jonathan Bennett

Michelle Lee Morris

Paul David Ratcliffe

Steven G Kultgen

Ronald Palin

Jui-Hsiang Chan

Andrew Stanley Edwards

Koc Kan Ho

The present invention relates to N-benzyl,N'-arylcarbonylpiperazine derivatives having the general formula I to pharmaceutical compositions comprising the same, and to the use of a these N-benzyl,N&#x2032;-arylcarbonylpiperazine derivatives for the manufacture of a medicament for treating or preventing atherosclerosis and related disorders associated with cholesterol and bile acids transport and metabolism.

N-benzyl,N'-arylcarbonylpiperazine derivatives

The present invention relates to isoxazole-3-carboxamide derivative having the general Formula (I), or a pharmaceutically acceptable salt thereof, to pharmaceutical compositions comprising the same, as well as to the use of said isoxazole-3-carboxamide derivatives for the treatment of TRPV1 mediated disorders, such as acute and chronic pain disorders, acute and chronic neuropathic pain, acute and chronic inflammatory pain, respiratory diseases, and lower urinary tract disorders. 

5-phenyl-isoxazole-3-carboxamide derivatives as TRPV1 modulators

A chemical genus of purinones and 1H-imidazopyridinones, which are useful as PKC&#x3b8;. inhibitors, and their methods of use are disclosed. The genus is represented by the formula I:   A representative example is: 

Purinones and 1H-imidazopyridinones as PKC-theta inhibitors

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Plainsboro, NJ, United States of America

Andrew Laird Roughton