Inotek Pharmaceuticals Corporation

Inotek Corporation

Yeda Research and Develpment & Co. Ltd

Inotek Pharmaceutical Corporation

Andrew L Salzman

Csaba Szabo

Prakash Jagtap

Garry Southan

John Henry Van Duzer

Siya Ram

Erkan Baloglu

Alex Nivorozhkin

Qi Zeng

William Williams, Iii

Kanneganti Murthy

Aloka Roy

Nurit Rachamim

Jon Mabley

Gary Southan

The invention relates to Purine Derivatives; compositions comprising an effective amount of a Purine Derivative; and methods for reducing an animal's rate of metabolism, protecting an animal's heart against myocardial damage during cardioplegia; or for treating or preventing a cardiovascular disease, a neurological disorder, an ischemic condition, a reperfusion injury, obesity, a wasting disease, or diabetes, comprising administering an effective amount of a Purine Derivative to an animal in need thereof.

Purine derivatives as adenosine A1 receptor agonists and methods of use thereof

The present invention provides a novel class of monoclonal antibodies which have a high affinity, broad spectrum neutralizing reactivity to flagellin from various Gram-negative bacteria including, but not limited to,and. The present invention further provides methods of treating inflammatory bowel disease (IBD) and methods of treating enterobacterial infections using anti-flagellin antibodies in humans, other animals and birds.

Antibodies against flagellin and uses thereof

[object Object]

The invention relates to Purine Derivatives having the formula;  The invention also relates to pharmaceutical compositions comprising an effective amount of the Purine Derivative; and methods for treating or preventing an ischemic condition, reperfusion injury, a cellular proliferative disorder, a cardiovascular disease, a neurological disorder, a skin disorder, a radiation-induced injury, a wound, or an inflammatory disease comprising administering an effective amount of the Purine Derivative to a subject in need thereof.

Purine derivatives and methods of use thereof

The invention relates to Purine Derivatives; compositions comprising an effective amount of a Purine Derivative; and methods for treating or preventing an ischemic condition, reperfusion injury, a cellular proliferative disorder, a cardiovascular disease, a neurological disorder, a skin disorder, a radiation-induced injury, a wound, or an inflammatory disease comprising administering an effective amount of a Purine Derivative to a subject in need thereof. The Purine Derivatives include compounds of the following formula: or a pharmaceutically acceptable salt thereof,wherein 

Purine Derivatives and methods of use thereof

The present invention relates to Purine Derivatives; compositions comprising an effective amount of a Purine Derivative; and methods for reducing an animal's core body temperature, protecting an animal's heart against myocardial damage during cardioplegia; or for treating or preventing a cardiovascular disease, a neurological disorder, an ophthalmic condition, an ischemic condition, a reperfusion injury, obesity, a wasting disease, or diabetes, comprising administering an effective amount of a Purine Derivative to an animal in need thereof. The Purine Derivatives include compounds of the following formula: or a pharmaceutically acceptable salt thereofwherein 

The invention provides novel classes of Isoquinoline Derivatives. Pharmaceutical compositions and methods of making and using the compounds, are also described.

Isoquinoline derivatives and methods of use thereof

The present invention relates to 5-Aryltetrazole Compounds, compositions comprising an effective amount of a a 5-Aryltetrazole Compound, and methods for treating an inflammation disease, a reperfusion disease, or hyperuricemia in an animal in need thereof comprising administering to the animal an effective amount of a 5-Aryltetrazole compound.

5-Aryltetrazole compounds and uses thereof

The present invention relates to 5-Aryltetrazole compounds, compositions comprising a 5-Aryltetrazole compound, and methods for treating an inflammation disease, a reperfusion disease, hyperuricemia, gout, or tumor-lysis syndrome in an animal in need thereof comprising administering to the animal an effective amount of a 5-Aryltetrazole compound.

5-Aryltetrazole compounds, compositions thereof, and uses therefor

Inosine compounds, compositions comprising an inosine compound and methods for treating or preventing an inflammation disease or a reperfusion disease comprising administering an effective amount of an inosine compound to a patient in need thereof are disclosed.

Inosine compounds and their use for treating or preventing an inflamation or a reperfusion disease

The invention provides a novel class of substituted nucleoside derivatives having the formula:A-Z1-L-Z2-Gwherein: Pharmaceutical compositions, and methods of making and using the compounds, or pharmaceutically acceptable salts, hydrates, or mixtures thereof are also described.

Nucleoside compounds and compositions thereof

The invention provides novel classes of substituted Indeno&lsqb;1,2-c&rsqb;isoquinoline Compounds. Pharmaceutical compositions and methods of making and using the compounds, are also described.

Growing community of inventors

Belmont, MA, United States of America

Andrew L Salzman