Northern Arizona University

Triad National Security, LLC

Dixie State University

University of California

The College of New Jersey

Los Alamos National Security, LLC

Arizona Board of Regents, a Body Corporate

Icagen, Inc.

Andrew Koppisch

Rico Del Sesto

David T Fox

Samir M Mitragotri

Robert Kellar

Michael Zakrewsky

Nathan Christopher Nieto

Joseph Baker

Katherine Lovejoy

Gerrick E Lindberg

Joshua R Greene

Alexanndra J Heyert

Benjamin P Warner

Anthony Keiran Burrell

T Mark McCleskey

Eva Rachel Birnbaum

Jennifer A Berger

Sharon M Baldwin

Michael Nathan Harris

Rico Emilio Del Sesto

Katherine S Lovejoy

Geraldine M Purdy

Jeffrey J Stewart

Methods and compositions related to molecules and formulations comprising antibiofilm materials are provide, including new formulations of Deep Eutectic Solvents (DES) that are chemically related to choline geranate. Specifically, geranic acid (a component of choline geranate DES) is a molecule from the isoprenoid/terpene family of compounds. Other members of this family as DES components include isoprenoid acids and chemical derivatives thereof.

Antibiofilm formulations

The compositions and methods described herein are topically applied to the skin with negligible or no skin irritation and can direct or prevent transport through the skin. The compositions contain neat ionic liquids, optionally in combination with a drug to be delivered. In a preferred embodiment, the compositions increase transdermal transport of the drug to be delivered. In some embodiments, the compositions disrupt bacterial biofilms. This is particularly beneficial in the treatment of antibiotic resistant skin infections. In other embodiments, the compositions direct delivery within the skin. In still other embodiments, the compositions prevent transfer of substances through the stratum corneum. The disclosed compositions and methods can be tuned and modified such that they can be used to treat or prevent a variety of different diseases and disorders.

Ionic liquids for transdermal drug delivery

Compositions for enhancing wound healing are disclosed herein. Also disclosed are methods of making the compositions and methods of using the compositions for the prevention of biofilm formation and for the inhibition of pathogen growth and proliferation.

Ionic liquids that sterilize and prevent biofilm formation in skin wound healing devices

X-ray fluorescence (XRF) spectrometry has been used for detecting binding events and measuring binding selectivities between chemicals and receptors. XRF may also be used for estimating the therapeutic index of a chemical. For estimating the binding selectivities of a chemical versus chemical analogs, for measuring post translational modification of proteins, and for drug manufacturing.

Advanced drug development and manufacturing

Phosphonium-based room temperature ionic liquids ('RTILs') were prepared. They were used as matrices for Matrix-Assisted Laser Desorption Ionization (MALDI) mass spectrometry and also for preparing samples of dyes for analysis.

Phosphonium-based ionic liquids and uses

Growing community of inventors

Flagstaff, AZ, United States of America

Andrew Koppisch