Allegheny-Singer Research Institute

Andrew Kassick

Saadyah Averick

Boyle Cheng

Michael Oh

This patent document discloses a modified polymer having increased hydrophilicity and a method of preparing the same.

Hydrophilic polyarylene ether ketone polymer and methods of forming same

Polymer conjugates comprising a hydrophobic biodegradable polymer covalently attached to a mu opioid receptor (MOR) antagonist are described. Biodegradable covalent nanoparticles comprising the hydrophobic biodegradable polymer covalently attached to a MOR antagonist are provided as a vehicle for the sustained delivery of the MOR antagonist. The described MOR antagonist delivery system may be used to more effectively prevent or overcome the toxic effects of synthetic opioids.

Covalent modification and controlled delivery of mu opioid receptor antagonists

This patent document discloses a modified polymer having increased hydrophilicity and a method of preparing the same. A polyarylene ether ketone polymer having a plurality of repeating units, wherein one or more units of the plurality of repeating units contains a hydrophilic N-substituted imine, which is derived from a ketone in the one or more units.

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Wexford, PA, United States of America

Andrew Kassick