Warner-lambert Company

Pfizer Corporation

Eli Lilly and Company

Andrew John Thorpe

David Juergen Wustrow

Justin Stephen Bryans

David Christopher Horwell

Po-wai Yuen

Charles David Jones

Brian Stephen Muehl

Jacob Bradley Schwarz

Christopher J Rito

Thomas Alan Crowell

Kenneth Jeff Thrasher

Anthony John Shuker

Charles Price Taylor, Jr

Deborah A Evrard

Thomas R Belliotti

David James Dooley

Nancy Sue Barta

Augustine Tobi Osuma

Lawrence D Wise

Clare Octavia Kneen

Christopher Peter Wayman

Robert Michael Schelkun

Norman Lloyd Colbry

Sean Donevan

Ihoezo Victor Ekhato

Zhijian Zhu

Pieter Hadewijn Van Der Graaf

Raymond Hudack, Jr

Kristin Knapp Lin

Thomas Richard Belliotti

Po-Wai Yuen

Lawrence David Wise

This invention relates to certain &#x3b2;-amino acids that bind to the alpha-2-delta (&#x3b1;2&#x3b4;) subunit of a calcium channel. These compounds and their pharmaceutically acceptable salts are useful in the treatment of a variety of psychiatric, pain and other disorders.

Amino acids with affinity for the &#x3b1;2&#x3b4;-protein

This invention relates to prodrugs of certain amino acids that bind to the alpha-2-delta (&#x3b1;2&#x3b4;) subunit of a calcium channel. These compounds and their pharmaceutically acceptable salts are useful in the treatment of a variety of psychiatric, pain and other disorders.

Prodrugs of amino acids with affinity for the &#x3b1;2&#x3b4;-protein

Use of an alpha-2-delta ligand, or a pharmaceutically acceptable derivative thereof, for the manufacture of a medicament for the treatment of premature ejaculation.

Method of treatment for sexual dysfunction

This invention relates to a method of treating a disorder selected from OCD, agoraphobia, agoraphobia without history of panic disorder, specific phobia, social phobia, PTSD, restless legs syndrome, premenstrual dysphoric disorder, hot flashes, and fibromyalgia by administering a compound of the formula 1 or a pharmaceutically acceptable salt thereof, wherein: Ris hydrogen, straight or branched alkyl of from 1 to 6 carbon atoms or phenyl; and Ris straight or branched alkyl of from 4 to 8 carbon atoms, straight or branched alkenyl of from 2 to 8 carbon atoms, cycloalkyl of from 3 to 7 carbon atoms, alkoxy of from 1 to 6 carbon atoms, -alkylcycloalkyl, -alkylalkoxy, -alkyl OH, -alkylphenyl, -alkylphenoxy, or -substituted phenyl. The invention also relates to a method of treating the above disorders by administering the compound (3S,5R)-3-Aminomethyl-5-methyl-octanoic acid.

Alpha 2 delta ligands for post-traumatic stress disorder

This invention relates to novel tetrazole and oxadiazalone &#x3b2;-amino acids derivatives of the formula wherein G is wherein Rthrough Rare defined as in the specification, pharmaceutical compositions containing them and their use for the treatment of various central nervous system and other disorders. The cyclopropyl &#x3b2;-amino acids derivatives of this invention exhibit activity as alpha2delta ligands (&#x3b1;2&#x3b4; ligands). Such compounds have affinity for the &#x3b1;2&#x3b4; subunit of a calcium channel.

Tetrazole and oxadiazolone substituted &#x3b2;-amino acid derivatives

This invention relates to a method of treating a disorder selected from OCD, agoraphobia, agoraphobia without history of panic disorder, specific phobia, social phobia, PTSD, restless legs syndrome, premenstrual dysphoric disorder, hot flashes, and fibromyalgia by administering a compound of the formula 1 or a pharmaceutically acceptable salt thereof, wherein:

Alpha2delta ligands for fibromyalgia and other disorders

The invention is a novel series of cyclic amino acids which are useful in the treatment of epilepsy, faintness attacks, neurodegenerative disorders, depression, anxiety, panic, pain, neuropathological disorders, gastrointestinal disorders such as irritable bowel syndrome (IBS), and inflammation, especially arthritis. A pharmaceutical composition containing a compound of the invention as well as methods of preparing the compounds and novel intermediates useful in the preparation of the final compounds are included.

Cyclic amino acids and derivatives thereof useful as pharmaceutical agents

Amino acids with affinity for the &#x3b1;-2-delta-protein

The present invention is in the field of medicine, particularly in the treatment of Type II diabetes and obesity. More specifically, the present invention relates to selective &bgr; receptor agonists useful in the treatment of Type II diabetes and obesity. The invention provides compounds and methods of treating type II diabetes and obesity, comprising administering to a mammal in need thereof compounds of the Formula I:

Selective &bgr;3 adrenergic agonists

Mono-and disubstituted 3-propyl gamma-aminobutyric acids

The instant invention is a novel series of amino heterocycles useful in the treatment of epilepsy, faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, panic, pain, neuropathological disorders, and sleep disorders. Processes for the preparation and intermediates useful in the preparation are also disclosed.

Amino heterocycles useful as pharmaceutical agents

Substituted gamma aminobutyric acids as pharmaceutical agents

Growing community of inventors

Whitmore Lake, MI, United States of America

Andrew John Thorpe