Anaptysbio, Inc.

Kyowa Kirin Co., Ltd.

Andrew John McKnight

David J King

Robert A Horlick

Marco Londei

Peter M Bowers

David Foster Mills

Shinya Ogawa

Yuji Yamazaki

Rachel Soloff Nugent

Aihua Song

John Lorca Laudenslager

Giuseppe Destito

Sarah Sunrise Bubeck

Aruna Bitra

Dirk Michael Zajonc

Peter Bowers

The invention relates to an isolated immunoglobulin heavy chain polypeptide and an isolated immunoglobulin light chain polypeptide that bind to a protein encoded by the interleukin 36 receptor (IL-36R). The invention provides an IL-36R-binding agent that comprises the aforementioned immunoglobulin heavy chain polypeptide and immunoglobulin light chain polypeptide. The invention also provides related vectors, compositions, and methods of using the IL-36R-binding agent to treat a disorder or disease that is responsive to IL-36R inhibition, such as cancer, an infectious disease, or an autoimmune disease.

Antibodies directed against interleukin 36 receptor (IL-36R)

An antibody or antigen binding fragment thereof that binds to a Fn14, wherein the antibody or antigen binding fragment thereof is an antagonist and non-agonist of Fn14.

FN14 antibodies and uses thereof

The invention relates to an isolated immunoglobulin heavy chain polypeptide and an isolated immunoglobulin light chain polypeptide that bind to interleukin-33 (IL-33). The invention provides an IL-33-binding agent that comprises the aforementioned immunoglobulin heavy chain polypeptide and immunoglobulin light chain polypeptide. The invention also provides related vectors, compositions, and methods of using the IL-33-binding agent to treat a disorder in a mammal that is responsive to IL-33 inhibition.

Method of treating autoimmune disease with antibodies against IL-33

Method of treating pustular psoriasis with antibodies directed against interleukin 36 receptor (IL-36R)

Method of treating inflammatory disorder with antibodies directed against interleukin-33 (IL-33)

Antibodies directed against interleukin-33 (IL-33) and methods of making and using

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San Diego, CA, United States of America

Andrew John McKnight