National Institutes of Health, a Component of the US Dept. of Health & Human Services

Andrew Jobson

Yves Pommier

Robert H Shoemaker

Michael Currens

Dominic Scudiero

John Cardellina

Christopher Self

Guangtao Zhang

David Waugh

George Lountos

A method of treating an Hepatitis C Virus infection in a patient, comprising providing a therapeutically effective amount, to a patient in need thereof, of a compound of Formula (I) or a pharmaceutically acceptable salt thereof, wherein: Gis a group of the formula or where n is 0, 1, 2, 3, or 4 and Het is a 5- or 6-membered heteroaryl group containing 1 to 4 heteroatoms independently chosen from N, O, and S, which Het is optionally substituted. 

Method of treating HCV infection with a small molecule CHK2 inhibitor

Described herein are Chk2-inhibitor compounds and derivatives thereof, and methods of treating or preventing disease and disease symptoms using the compounds and compositions thereof.

Use of Chk2 kinase inhibitors for cancer treatment

Growing community of inventors

Coventry, United Kingdom

Andrew Jobson