University of Cincinnati

Eccrine Systems, Inc.

Andrew Jajack

Jason C Heikenfeld

Michael Charles Brothers

Jacob A Bertrand

Isaac Stamper

Eliot Gomez

Described are devices for and methods of modulating a fluid sample. The devices () include at least one sample-modulating component (, and) and, in some embodiments, two or more sample-modulating components. The sample-modulating components are each capable of performing a function selected from the following group: concentrating the sample to increase a concentration of a first constituent of the sample; diluting the sample to decrease a concentration of a second constituent in of the sample; desalinating the sample to decrease the total moles of salt in the sample volume or causing a temporary decrease in the osmolarity; adjusting pH of the sample to bring a pH of the sample into a predetermined range; absorbing one or more nonpolar substances to decrease a concentration of the nonpolar substances; and delivering one or more reagents to the sample to provide a desired concentration of the reagent in the sample.

Devices and methods for processing fluid samples

The disclosed invention provides a fluid sensing device and method capable of collecting a fluid sample, concentrating the sample with respect to one or more target analytes, and measuring the target analyte(s) in the concentrated sample. The invention is also capable of determining the change in molarity of the fluid sample with respect to the target analyte(s), as the sample is concentrated by the device. The invention further includes a method for using a fluid sensing device to concentrate a fluid sample with respect to one or more target analytes. The disclosed method further includes the ability to correlate the measured target analyte concentration to a physiological condition of a device wearer, or of a fluid source.

Devices capable of fluid sample concentration for extended sensing of analytes

A device for increasing a concentration of at least one analyte in an advective flow of biofluid includes an agent for enhancing a paracellular permeability of an epithelial tissue; and an iontophoresis electrode and a counter electrode, which are adapted to increase the concentration of said analyte in the advective flow of the biofluid. A method of sensing an analyte in a biofluid includes increasing a paracellular permeability of an epithelial tissue layer; and inducing electro-osmotic flow by reverse iontophoresis to increase a concentration of said analyte in an advective flow of the biofluid, wherein said advective flow is driven by at least one of saliva generation, sweat generation, or reverse iontophoresis.

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Cincinnati, OH, United States of America

Andrew Jajack