Mds Inc.

Perseptive Biosystems Inc.

Applera Corporation

Eisai Inc.

Mgi Pharma Biologics, Inc.

Agenus Inc.

Andrew J Tomlinson

Mary Lynne Hedley

Robert G Urban

Nazneen Aziz

Geoffrey Cole

Lawrence A Haff

Jennifer M Campbell

Timothy E Hutchins

Philip J Savickas

Igor P Smirnov

Peter Juhasz

Michael P Donegan

Perumanath H Nair

Kenneth P Leclair

Cheryl E Murphy

The present invention provides nucleic acids containing transcriptional units that encode CYP1B1 polypeptides or portions thereof, wherein the transcriptional units lack sequences found in the untranslated region (UTR) of naturally occurring forms of the CYP1B1 transcript. The nucleic acids of the invention lack translational repressor elements and thus provide for a system of enhanced translation of the CYP1B1 polypeptide or portions thereof. Also disclosed are methods of administering nucleic acids to a mammal and use in the treatment of proliferative disorders or cancer.

CYP1B1 nucleic acids and methods of use

A MALDI plate suitable for MS or MS-MS analysis provided with a composite coating that comprises a hydrophobic coating and a thin layer coating of a mixture of a MALDI matrix material and an intercalating agent such as a polymer is disclosed. A MALDI plate produced in accordance with the present teachings is useful for suppression of matrix ions in the low mass region (&#x3c;1,000 daltons) of a MALDI-MS spectrum.

Reduction of matrix interference for MALDI mass spectrometry analysis

A sample plate for a MALDI process is provided which comprises an electrically conductive substrate having a hydrophobic coating whose thickness and hydrophobic character can be modified by changing the coating substrate and/or the concentration of the substrate. Different coating substances that have provided optimal performance of the sample plate for reproducible deposition and analysis by MALDI-MS and MALDI-MS/MS processes of analyte mixtures include synthetic waxes such as paraffin compositions, lipids, organic acids, silicon-containing compounds, silica polymers and natural waxes. Metal polishes that have been used to clean and regenerate plate surfaces have also provided a sample plate that has optimal performance for reproducible deposition and analysis by MALDI-MS and MALDI-MS/MS processes of analyte mixtures.

MALDI plate and process for making a MALDI plate

A sample plate structure is provided including a retainer plate having a central opening, a sample insert plate which fits into the opening, an optional pressure plate and a handle. The handle applies pressure to the sample insert plate to retain it within the retainer plate. The sample insert plate is provided with a peripheral configuration, which assures that the sample insert plate is properly oriented within the sample plate support structure and is held flat. While the sample insert plate can be a consumable, the remaining portion of the apparatus can be reused.

MALDI plate with removable insert

Growing community of inventors

Wayland, MA, United States of America

Andrew J Tomlinson