Bayer Healthcare LLC

Ascensia Diabetes Care Holdings Ag

Bayer Corporation

Andrew J Edelbrock

Steven C Charlton

Dijia Huang

Matthew K Musho

Amy H Chu

Huan-Ping Wu

Sung-Kwon Jung

J Oakey Noell

Suny J George

Mu Wu

Matthew B Holzer

Jeffery S Reynolds

Paul M Ripley

John P Creaven

Xin Wang

Narasinha C Parasnis

Swetha Chinnayelka

Steve Hoi-Cheong Sun

Joseph E Perry

Russell J Micinski

Hope G Spradlin

Greg P Beer

Hope Spradlin

Mark S Vreeke

Yingping Deng

Sherry J Jamison

Oakey J Noell

A biosensor system determines an analyte concentration of a biological sample using an electrochemical process without Cottrell decay. The biosensor system generates an output signal having a transient decay, where the output signal is not inversely proportional to the square root of the time. The transient decay is greater or less than the &#x2212;0.5 decay constant of a Cottrell decay. The transient decay may result from a relatively short incubation period, relatively small sample reservoir volumes, relatively small distances between electrode surfaces and the lid of the sensor strip, and/or relatively short excitations in relation to the average initial thickness of the reagent layer. The biosensor system determines the analyte concentration from the output signal having a transient decay.

Determining analyte concentration from variant concentration distribution in measurable species

A test sensor includes a body, a first conductive trace, a second conductive trace, and a third conductive trace. The body includes a first region that has a fluid-receiving area, a second region separate from the first region, and a first temperature sensing interface disposed at or adjacent to the fluid-receiving area. The fluid-receiving area receives a sample. The first trace is disposed on the body, and at least a portion of the first trace is disposed in the first region. The second and third traces are disposed on the body. The third trace extends from the first to the second regions. The third trace is connected to the first trace at the first temperature sensing interface. The third trace includes a different material than the first trace. A first thermocouple is formed at the first temperature sensing interface. The thermocouple provides temperature data to determine an analyte concentration.

System and apparatus for determining temperatures in a fluid analyte system

According to one embodiment of the present invention, an electrochemical sensor () for detecting the concentration of analyte in a fluid test sample is disclosed. The sensor () includes a counter electrode having a high-resistance portion for use in detecting whether a predetermined amount of sample has been received by the test sensor.

Electrochemical biosensor

An electrochemical test sensor for detecting the analyte concentration of a fluid test sample includes a base, a dielectric layer, a reagent layer and a lid. The base provides a flow path for the test sample having on its surface a counter electrode and a working electrode adapted to electrically communicate with a detector of electrical current. The dielectric layer forms a dielectric window therethrough. The reagent layer includes an enzyme that is adapted to react with the analyte. The lid is adapted to mate with the base and to assist in forming a capillary space with an opening for the introduction of the test sample thereto. At least a portion of the width of the counter electrode is greater than the width of the working electrode.

Electrochemical test sensor with reduced sample volume

Transient decay amperometry biosensors

An electrochemical test sensor adapted to assist in determining the concentration of analyte in a fluid sample is disclosed. The sensor comprises a base that assists in forming an opening for introducing the fluid sample, a working electrode being coupled to the base, and a counter electrode being coupled to the base, the counter electrode and the working electrode being adapted to be in electrical communication with a detector of electrical current, and a sub-element being coupled to the base. A major portion of the counter electrode is located downstream relative to the opening and at least a portion of the working electrode. The sub-element is located upstream relative to the working electrode such that when electrical communication occurs between only the sub-element and the working electrode there is insufficient flow of electrical current through the detector to determine the concentration of the analyte in the fluid sample.

Electrochemical-sensor design

A test sensor reagent for measuring the concentration of analytes in body fluids includes cellulose polymers for improving the stability of the test sensor and reducing the total assay time. The test sensor reagent also includes an enzyme, an electron transfer mediator and a rheological additive.

Test sensor reagent having cellulose polymers

Methods of using an electrochemical biosensor

Transient decay amperometry

A method of forming and using an auto-calibration circuit or label on a test sensor includes providing a label or circuit. The label or circuit includes a first layer, a second layer and a lamination portion. The second layer is located between the first layer and the lamination portion. The first layer includes polymeric material. The second layer includes conductive material. The label or circuit is applied to the test sensor via the lamination portion. After applying the label or circuit to the test sensor, portions of the second layer are ablated using a laser to form an auto-calibration pattern on the label or circuit.

Method of forming an auto-calibration circuit or label

Growing community of inventors

Granger, IN, United States of America

Andrew J Edelbrock