Alza Corporation

Andrew I Poutiatine

Jeffrey Wayne Etter

Patrick S-l Wong

Nathan Roth

Vincent Joseph Ferrari

James Horvath

Miriam A Martin

Christopher M Ohms

J Richard Gyory

Armand P Neukermans

Joseph Creagan Trautman

Michel J N Cormier

Wai-Loong Lim

Wei-Qi Lin

Hyunok Lynn Kim

Christopher M G Ohms

Kellee Eng

Sara L Sendelbeck

Bruce P Edwards

A device and method for enhancing skin piercing by microprotrusions involves pre-stretching the skin to enhance pathway formation when the microprotrusions are pressed into the skin. An expandable device includes skin engaging opposite ends that contact the skin surface so that when the device is expanded the skin is stretched. The skin is placed under a tension of about 0.01 to about 10 megapascals, preferably about 0.05 to 2 megapascals. The device has a plurality of microprotrusions which penetrate the skin while the skin is being stretched by the expanded device. Another stretching device employs suction for skin stretching.

Device and method for enhancing skin piercing by microprotrusions

Oral active agent delivery system having improved flow controllers. A hollow tubular member containing the active agent formulation and having a fluid passing controller is placed at one end into a fluid and at a second end into a patient's mouth. The active agent is delivered when the patient sips on the end of the chamber. The improved controllers prevent leakage of the active agent formulation.

Flow controller configurations for an active agent delivery device

The present invention is directed to an oral active agent delivery system comprising improved flow controllers. A hollow tubular member (10) containing the active agent formulation and having a fluid passing controller (14) is placed at one end (16) into a fluid and at a second end (18) into a patient's mouth. The active agent is delivered when the patient sips on the end of the chamber. The improved controllers prevent leakage of the active agent formulation.

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Menlo Park, CA, United States of America

Andrew I Poutiatine