Berlex Laboratories, Inc.

Optimize Technologies, Inc.

Andrew I Chitty

John T Martin

Raju Mohan

Michael M Morrissey

Brad Owen Buckman

Saleh Mohammed Mirani

Multiple chemical reactions are performed in a plurality of reaction vessels mounted in inlets in a manifold valve block. The manifold valve block is connected to a channel block which is utilized in conjunction with a solvent delivery system as part of the reaction cycle. The solvent fluid is drained from the reaction vessels when valves in the manifold valve block are opened while applying a vacuum thereto. Optionally, a thermal block may be utilized in conjunction with the manifold valve block and the channel block to facilitate the reaction. Upon completion of the reactant cycle, the manifold valve block is disconnected from the channel block and connected to a cleavage block assembly which contains vials for collecting reaction products. The cleavage product is drained from the reaction vessels through the manifold valve block into the vials upon opening the valves in the manifold valve block and applying a vacuum to the channel block.

Apparatus and process for multiple chemical reactions

A fitting assembly (10) mates an end of polymer micro-tubing (12) in fluid communication with an internally threaded connector (22) having an internal bottom wall (38). The fitting assembly includes a male nut (16) having external threads and a passage for receiving the end of the polymer micro-tubing. The fitting assembly additionally includes an insert (24) having an elongated stem (30) and an annular head (26). The stem projects from the rear side of the annular head for insertion into the end of the polymer micro-tubing. The annular head includes a forwardly projecting nose section (31). An elastomeric seal (40) is received on the nose section (31) and retained in place by a lip (33) included on the nose section. The seal is compressed between the head of the insert and the bottom wall of the connector. A ferrule (32) captured on the micro-tubing between the nut and the head of the insert compresses the tubing between the ferrule and the stem, and transmits force longitudinally to the head of the insert to compress the seal.

Miniature fitting assembly for micro-tubing

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West Linn, OR, United States of America

Andrew I Chitty