Inhibrx, Inc.

Inhibrx Biosciences, Inc.

Andrew Hollands

Brendan P Eckelman

John C Timmer

William Crago

Milton Ma

Kyle S Jones

Quinn L Deveraux

Angelica N Sanabria

Chelsie Macedo

Jacob Gano

Provided herein are VHH-containing polypeptides that bind CD33. Uses of the VHH-containing polypeptides are also provided.

CD33-binding polypeptides and uses thereof

Provided herein are VHH-containing polypeptides that bind CD123. Uses of the VHH-containing polypeptides are also provided.

CD123-binding polypeptides and uses thereof

This invention relates generally to molecules that specifically bind bacterial V-tip proteins of the type III secretion system of Gram negative bacteria such as PcrV from. More specifically, this invention relates to molecules that block the injection of effector molecules into target cells. This invention also relates to molecules that specifically bind to bacterial lipoproteins, such as OprI. The molecules of the present invention are monospecific or multispecific and can bind their target antigen in a monovalent or multivalent manner. The invention also relates generally to molecules that specifically bind bacterial cell surface proteins such as OprI, and to methods of use these molecules in a variety of therapeutic, diagnostic, and/or prophylactic indications.

Type III secretion system targeting molecules

Growing community of inventors

La Jolla, CA, United States of America

Andrew Hollands