Vanderbilt University

Andrew Harmata

Scott A Guelcher

Katarzyna Jadwiga Zienkiewicz

Jerald E Dumas

Edna Margarita Prieto

Anne Talley

Embodiments of the present inventions comprise composites of polyurethane(s), osteoconductive matrix, and, optionally, a growth factor. Embodiments further comprise methods of making such composite and uses thereof. The osteoconductive matrix can be a tricalcium phosphate, bioglass, or the like, and can include particles that are surface modified. Growth factors can be provided in powder form, including bone morphogenic proteins such as rhBMP-2. A composition may be moldable and/or injectable. After implantation or injection, a composition may be set to form a porous composite that provides mechanical strength and supports the in-growth of cells.

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Nashville, TN, United States of America

Andrew Harmata