Medtronic Ardian Luxembourg S.a.r.l.

Medtronic Ireland Manufacturing Unlimited Company

Other

Axon Therapies, Inc.

Zoll Circulation, Incorporated

Otsuka Medical Devices Co., Ltd.

Radiant Medical, Inc.

Ablacare, Inc.

Ardian, Inc.

Andrew H Wu

Denise Marie Zarins

Benjamin J Clark

Nicolas Zadno

Mark S Leung

Hanson Gifford

Mark E Deem

Kenneth J Michlitsch

Erik Thai

Robert J Beetel

Mark Gelfand

Paul Brian Friedrichs

Sowmya Ballakur

David Herzfeld

Vincent W Ku

Maria G Aboytes

Dorin Panescu

Denise M Demarais

David Jerry Scott

Jeffrey P Callister

Zoar Jacob Engelman

Paul M Stull

Howard R Levin

Robin B Bek

James Mazzone

Howard Levin

Kevin M Mauch

Jignesh H Shah

Neil Chand Barman

Kristen Easterday

Ryan J Hilaman

Charles Richard Lewis, Jr

Jeff Gamelsky

Eric Dailey

Min-Yu Wu

Venmathi Gunasekaran

Justin Goshgarian

William R George

Michele Lee Silver

William W Chang

Leonila Rivera

Julie Trudel

Sukyoung Shin

Garrett Marc Schwab

Sina Som

John Paul Sam

Juanita Sanchez-Cole

Mario Alvarado

Hadar Cadouri

Mark Deem

Kyle Doerksen

Don S Minami

Dave Vondle

Michael Harboun

Simon King

Juanita Sanchez Cole

Benjamin C Clark

The present disclosure relates to devices, systems and methods for evaluating the success of a treatment applied to tissue in a patient, such as a radio frequency ablative treatment used to neuromodulate nerves associated with the renal artery. A system monitors parameters or values generated during the course of a treatment. Feedback provided to an operator is based on the monitored values and relates to an assessment of the likelihood that a completed treatment was technically successful. In other embodiments, parameters or values generated during the course of an incomplete treatment (such as due to high temperature or high impedance conditions) may be evaluated to provide additional instructions or feedback to an operator.

Devices, systems and methods for evaluation and feedback of neuromodulation treatment

Catheter apparatuses, systems, and methods for achieving renal neuromodulation by intravascular access are disclosed herein. One aspect of the present technology, for example, is directed to a treatment device having a multi-electrode array configured to be delivered to a renal blood vessel. The array is selectively transformable between a delivery or low-profile state (e.g., a generally straight shape) and a deployed state (e.g., a radially expanded, generally helical shape). The multi-electrode array is sized and shaped so that the electrodes or energy delivery elements contact an interior wall of the renal blood vessel when the array is in the deployed (e.g., helical) state. The electrodes or energy delivery elements are configured for direct and/or indirect application of thermal and/or electrical energy to heat or otherwise electrically modulate neural fibers that contribute to renal function or of vascular structures that feed or perfuse the neural fibers.

Catheter apparatuses having multi-electrode arrays for renal neuromodulation and associated systems and methods

Medical apparatus

Systems, devices, and methods for transvascular ablation of target tissue are disclosed herein. The devices and methods may, in some examples, be used for splanchnic nerve ablation to increase splanchnic venous blood capacitance to treat at least one of heart failure and hypertension. For example, the devices disclosed herein may be advanced endovascularly to a target vessel in the region of a thoracic splanchnic nerve (TSN), such as a greater splanchnic nerve (GSN) or a TSN nerve root. Also disclosed are method of treating heart failure, such as HFpEF, by endovascularly ablating a thoracic splanchnic nerve to increase venous capacitance and reduce pulmonary blood pressure.

Methods and devices for endovascular ablation of a splanchnic nerve

Methods and system are provided for thermally-induced renal neuromodulation. Thermally-induced renal neuromodulation may be achieved via direct and/or via indirect application of thermal energy to heat or cool neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers. In some embodiments, parameters of the neural fibers, of non-target tissue, or of the thermal energy delivery element, may be monitored via one or more sensors for controlling the thermally-induced neuromodulation. In some embodiments, protective elements may be provided to reduce a degree of thermal damage induced in the non-target tissues. In some embodiments, thermally-induced renal neuromodulation is achieved via delivery of a pulsed thermal therapy.

Devices for thermally-induced renal neuromodulation

Systems, devices, and methods for transvascular ablation of target tissue. The devices and methods may, in some examples, be used for splanchnic nerve ablation to increase splanchnic venous blood capacitance to treat at least one of heart failure and hypertension. For example, the devices disclosed herein may be advanced endovascularly to a target vessel in the region of a thoracic splanchnic nerve (TSN), such as a greater splanchnic nerve (GSN) or a TSN nerve root. Also disclosed are method of treating heart failure, such as HFpEF, by endovascularly ablating a thoracic splanchnic nerve to increase venous capacitance and reduce pulmonary blood pressure.

Apparatus, systems, and methods for achieving thermally-induced renal neuromodulation by intravascular access are disclosed herein. One aspect of the present application, for example, is directed to apparatuses, systems, and methods that incorporate a treatment device comprising an elongated shaft. The elongated shaft is sized and configured to deliver a thermal element to a renal artery via an intravascular path. Thermally-induced renal neuromodulation may be achieved via direct and/or via indirect application of thermal energy to heat or cool neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers.

Apparatus, systems, and methods for achieving intravascular, thermally-induced renal neuromodulation related application

Catheter assemblies for neuromodulation proximate a renal artery bifurcation and associated systems and methods are disclosed herein. A catheter assembly configured in accordance with a particular embodiment of the present technology can include a shaft having a proximal portion, a distal portion, and two therapeutic arms extending from the distal portion. The shaft can be configured to deliver the distal portion to a treatment site proximate a branch point or bifurcation in a renal blood vessel. The therapeutic arms can include energy delivery elements that are configured to deliver the therapeutically-effective energy to renal nerves proximate the branch point.

Catheter assemblies for neuromodulation proximate a bifurcation of a renal artery and associated systems and methods

Described here are methods and systems for the manipulation of ovarian tissues. The methods and systems may be used in the treatment of polycystic ovary syndrome (PCOS). The systems and methods may also be useful in the treatment of infertility associated with PCOS.

Methods and systems for the manipulation of ovarian tissues

Growing community of inventors

San Jose, CA, United States of America

Andrew H Wu