Wyeth

Other

Ligand Pharmaceuticals, Inc.

Andrew Fensome

Jay Edward Wrobel

James Patrick Edwards

Lin Zhi

Todd Kevin Jones

Christopher Michael Tegley

Puwen Zhang

Eugene Anthony Terefenko

Edward George Melenski

Casey Cameron McComas

Gary Sondermann Grubb

John W Ullrich

Michael Anthony Marella

Lori L Miller

Horace Fletcher, Iii

Mark A Collins

Reinhold H W Bender

Richard Page Woodworth, Jr

Marci C Koko

Arthur Attilio Santilli

Thomas Joseph Commons

Gavin David Heffernan

Diane Deborah Harrison

Andrew Q Viet

Michael Byron Webb

Richard Winneker

Ronald Charles Bernotas

Jeffrey Curtis Kern

Joel Adam Goldberg

Eugene John Trybulski

Stephen Todd Cohn

Joseph Peter Sabatucci

An Thien Vu

Charles William Mann

David John O'Neill

Reinhold Hw Bender

Methods of using compounds which are progesterone receptor agonists for contraception and the treatment of progesterone-related maladies alone or in combination with an estrogen receptor agonist or progesterone receptor antagonist are provided. These compounds have the structure: wherein R, R, R, R, R, and Qare defined herein.

Cyclothiocarbamate derivatives as progesterone receptor modulators

The present invention provides methods of inducing contraception which includes delivering to a female a composition containing a compound of formula I, or tautomers thereof, in a regimen which involves delivering one or more of a selective estrogen receptor modulator, wherein formula I is: and wherein R-Rand Qare defined as described herein. Methods of providing hormone replacement therapy and for treating carcinomas, dysfunctional bleeding, uterine leiomyomata, endometriosis, and polycystic ovary syndrome is provided which includes delivering a compound of formula I and a selective estrogen receptor modulator are also described.

Methods of treating hormone-related conditions using thio-oxindole derivatives

Compounds of the following structure are provided, wherein n, R-Rand R-Rare defined below, as are methods of preparing and using these compounds for contraception; treating or preventing fibroids, uterine leiomyomata, endometriosis, dysfunctional bleeding, polycystic ovary syndrome, and hormone-dependent carcinomas; providing hormone replacement therapy; stimulating food intake; synchronizing estrus; and treating cycle-related symptoms. 

Sulfonylated heterocycles useful for modulation of the progesterone receptor

In one embodiment, compounds of the following structure are described, wherein Rto Rare described herein.  Also provided are methods for preparing these compounds and methods of contraception; treating or preventing fibroids; treating or preventing uterine leiomyomata; treating or preventing endometriosis, dysfunctional bleeding, and polycystic ovary syndrome; treating or preventing hormone-dependent carcinomas; providing hormone replacement therapy; stimulating food intake; synchronizing estrus; and treating cycle-related symptoms using the compounds described herein.

Aryl sulfonamides useful for modulation of the progesterone receptor

The present invention is directed to substituted benzothiadiazinedioxide derivatives of formula I: or a pharmaceutically acceptable salt, stereoisomer or tautomer thereof, which are monoamine reuptake inhibitors, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions, including, inter alia, vasomotor symptoms, sexual dysfunction, gastrointestinal disorders and genitourinary disorder, depression disorders, endogenous behavioral disorders, cognitive disorders, diabetic neuropathy, pain, and other diseases or disorders.

Substituted benzothiadiazinedioxide derivatives and methods of their use

Progesterone receptor modulators of formula I, or a pharmaceutically acceptable salt thereof, wherein R, R, R, R, R, Rand Rare as defined herein. These compounds are useful for contraception and hormone replacement therapy. Also provided are products containing these compounds.

Cyanopyrrole-phenyl amide progesterone receptor modulators and uses thereof

Compounds of the following structure are described: wherein R-R, R, m, V, X, Y, Z and Q are described herein, or a pharmaceutically acceptable salt, tautomer, metabolite or prodrug thereof. These compounds are useful for treating a variety of hormone-related conditions including contraception, treating or preventing fibroids, endometriosis, dysfunctional bleeding, uterine leiomyomata, polycystic ovary syndrome, or hormone-dependent carcinomas, providing hormone replacement therapy, stimulating food intake or synchronizing estrus.

Imidazolidin-2-one derivatives useful as PR modulators

Compounds of the following structure are described: wherein R-R, m, V, W, X, Y, Z and Q are described herein, or a pharmaceutically acceptable salt, tautomer, metabolite or prodrug thereof. These compounds are useful for treating a variety of hormone-related conditions including contraception, treating or preventing fibroids, endometriosis, dysfunctional bleeding, uterine leiomyomata, polycystic ovary syndrome, or hormone-dependent carcinomas, providing hormone replacement therapy, stimulating food intake or synchronizing estrus.

Oxazolidine derivatives as PR modulators

This invention relates to substituted indoline derivative compounds which are antagonists of the progesterone receptor, their preparation and pharmaceutical utility, particularly including contraception and treatment of benign or malignant neoplastic diseases, having the general structure: wherein Rand Rmay be single substituents or fused to form spirocyclic rings.

Indoline derivatives

Compounds of the following structure are described: wherein R, R, R, R, V, X, Y, Z and Q are described herein, or a pharmaceutically acceptable salt, tautomer, metabolite or prodrug thereof. These compounds are useful for treating a variety of hormone-related conditions including contraception, treating or preventing fibroids, endometriosis, dysfunctional bleeding, uterine leiomyomata, polycystic ovary syndrome, or hormone-dependent carcinomas, providing hormone replacement therapy, stimulating food intake or synchronizing estrus.

Oxazolidone derivatives as PR modulators

Compounds of the following structure are described: wherein R-R, R, m, V, W, X, Y, and Q are described herein, or a pharmaceutically acceptable salt, tautomer, metabolite or prodrug thereof. These compounds are useful for treating a variety of hormone-related conditions including contraception, treating or preventing fibroids, endometriosis, dysfunctional bleeding, uterine leiomyomata, polycystic ovary syndrome, or hormone-dependent carcinomas, providing hormone replacement therapy, stimulating food intake or synchronizing estrus.

Tricyclic oxazolidone derivatives useful as PR modulators

The present invention is directed to aryl sulfamide derivatives of formula I: or a pharmaceutically acceptable salt, stereoisomer or tautomer thereof, which are monoamine reuptake inhibitors, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions, including, inter alia, vasomotor symptoms, sexual dysfunction, gastrointestinal disorders and genitourinary disorder, depression disorders, endogenous behavioral disorders, cognitive disorders, diabetic neuropathy, pain, and other diseases or disorders.

Aryl sulfamide derivatives and methods of their use

Growing community of inventors

Wayne, PA, United States of America

Andrew Fensome