The Scripps Research Institute

Other

Janssen Pharmaceutica

Andrew E Parker

Walter H M L Luyten

Clare H McGowan

Alessandra Blasina

The invention provides for a novel human checkpoint kinase gene, hCDS1, comprising the nucleic acid sequence of residues 66-1694 of SEQ ID NO: 1, a protein expressed from the gene, fragments and functional equivalents of the protein. The invention also provides for pharmaceutical compositions comprising a hCDS1 protein, and methods utilizing the protein.

Human checkpoint kinase, hCDS1, compositions and methods

The invention provides for a novel human checkpoint kinase gene, hCDS1, translated protein, compositions, methods, and kits.

Polynucleotide encoding hCDS1, a human cell-cycle checkpoint kinase

The invention provides for a novel human checkpoint kinase gene, hCDS 1, translated protein, compositions, methods, and kits.

Human checkpoint kinase, HCDS1, compositions and methods

A device for opening ampoules comprises a hollow cylindrical body, the peripheral wall of which has slits forming two halves which can flex relatively apart or together at an open end of said body to enable entry of an ampoule head portion and for ejection of a broken head portion respectively. The body is dimensioned to accommodate an ampoule head and an inwardly-directed annular bead is provided at the open end against which the neck of an ampoule can be broken. A cutter protrudes from the bead. The bead is provided at the convergence of an outwardly-directed peripheral flange and an inwardly-directed annular ramp. A plunger whose piston is hollow is provided in the body to eject broken ampoule heads.

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Cheshire, United Kingdom

Andrew E Parker