Minipumps, LLC

Wang, Bin

Urazaki, Andrew

Jiang, Fukang

Dunn, Andrew

Andrew Dunn

Jason Shih

Fukang Jiang

Changgeng Liu

Andrew Urazaki

Mark Salman Humayun

William Andrew Brandt

Pedrum Minaie

Atoosa Lotfi

Didier Sagan

Gregory Harbers

Brandon Curley

Bin Wang

Richard Purvis

Miho Matsuoka

Andres Rodriguez

Tun Min Soe

In various embodiments, a drug pump includes a housing and, within the housing, an expandable drug reservoir at least part of which is exposed to a pressurized propellant. The propellant exerts a substantially constant pressure on the drug reservoir. A flow restrictor significantly limits outflow from the pump, and preferably has both a small diameter and a long path length, which acts to control the outflow from the drug reservoir. As a result, the pump produces a substantially constant outflow.

Implantable continuous-flow pumps

Embodiments of the present invention involve a refill apparatus comprising at least one pump, a plurality of reservoirs, a plurality of reservoir fluid channels each associated with one of the reservoirs, a plurality of valves, each having a cracking pressure, for fluidically sealing the reservoir fluid channels and the outlet fluid channel, an outlet fluid channel fluidically connected to the reservoir fluid channels, and a needle having a lumen in fluid communication with the outlet fluid channel. A parameter such as a pressure level is monitored, and one or more pumps and various ones of the valves are actuated in accordance with a protocol comprising a sequence of steps whereby fluidic pathways are opened between different ones of the reservoirs and the needle in a washing and filling sequence, each of the steps being associated with an expected pressure level.

Drug refill applicator system and method of use

Tubular polymeric structures are formed by creating a convex mold conforming to a fluid pathway design, depositing a coating of polymer over the mold, and in situ removing the mold without drawing it against the polymer. The resulting structures are fabricated with flow-altering features.

Flexible manufacture of polymeric tubing including flow-altering structures

In various embodiments, approaches to calibrating an implantable drug-delivery device feature a drug reservoir, an expandable electrolysis chamber, and an integrated strain gauge using a refill apparatus having one or more pumps, one or more refill reservoirs, an outlet fluid channel fluidically connected to the refill reservoir(s), and a needle having a lumen in fluid communication with the outlet fluid channel include inserting a needle into a refill port of the implantable drug-delivery device, monitoring a pressure change within the device, monitoring a pressure level of one or more components of the implantable drug-delivery device, and calibrating the monitored pressure level of the component(s) of the implantable drug-delivery device to the monitored pressure level of the outlet fluid channel.

Pressure sensing in implantable drug pumps

Tubular polymeric structures are formed by creating a convex mold conforming to a fluid pathway design, depositing a coating of polymer over the mold, and in situ removing the mold without drawing it against the polymer.

Flexible manufacture of polymeric tubing

Growing community of inventors

Santa Monica, CA, United States of America

Andrew Dunn