The UAB Research Foundation (the University of Alabama at Birmingham)

Southern Research Institute

Advanced Tear Diagnostics, Llc.

Andrew Douglas Penman

Joanne Murphy-Ullrich

Sergei A Svarovsky

Andrew Wayne Cain

Marcus Willard Smith

Andra Rixse Frost

Timothy M Wick

Joel L Berry

Catalina Valencia

The presence of biomarkers or other analytes can be detected in the bodily fluid using Electrochemical Impedance Spectroscopy (EIS) or Electrochemical Capacitance Spectroscopy (ECS) in devices, such as handheld point-of-care devices. The devices, as well as systems and methods, utilize using Electrochemical Impedance Spectroscopy (EIS) or Electrochemical Capacitance Spectroscopy (EIS) in combination with an antibody or other target-capturing molecule on a working electrode. Imaginary impedance or phase shift, as well as background subtraction, also may be utilized.

Point-of-care apparatus and methods for detecting cancer using electrochemical impedance or capacitance spectroscopy

Three-dimensional (3D), prevascularized, engineered tissue constructs, 3D prevascularized engineered tissue models of cancer, and bioreactors and bioreactor arrays including the tissue constructs are disclosed. Methods of making the tissue constructs, methods of using the tissue constructs, methods of drug discovery using the tissue constructs and/or cancer models, and the like are also disclosed.

Three-dimensional, prevascularized, engineered tissue constructs, methods of making and methods of using the tissue constructs

Growing community of inventors

Birmingham, AL, United States of America

Andrew Douglas Penman