Senseonics, Incorporated

Sensors for Medicine & Science, Inc.

Andrew Dehennis

Todd Whitehurst

James Masciotti

Xiaoxiao Chen

Szymon Tankiewicz

Abhi Chavan

Ravi Rastogi

Arthur Earl Colvin

Barkha Raisoni

Barbara Montgomery

Patricia Sanchez

Jeremy Emken

Philip Huffstetler

Mark Mortellaro

Venkata Velvadapu

Joshua C Schaefer

Tina HyunJung Kim

Jason D Colvin

Jody L Krsmanovic

Kamuran Turksoy

Xiaolin Wang

Colleen Mdingi

David Lerner

Bryan Hays

Arthur E Colvin

Suresh Addaguduru

Erman Citirik

Samanwoy Ghosh-Dastidar

Samanwoy Ghosh Dastidar

Alexander Markovic

Yahya Hosseini

Christina Long

Simone Faccioli

Srinivasan Rajaraman

Eitan Saba-Keren

Alex Markovic

Shang Zhao

Phil Huffstetler

Barkha Rasioni

Venkata Velvaldupa

A method for determining the average usage of an analyte monitoring system may include the step of calculating one or more analyte measurements of a host during a first period of time. The method may include the step of calculating a duration of time that the host uses the analyte monitoring system during the first period of time. The method may include the step of calculating an average time that the host uses the analyte monitoring system during a second period of time or a percentage of the first period of time that the host uses the analyte monitoring system, in which the average time or the percentage is calculated based on at least the calculated duration. The method may include the step of generating and displaying a report indicating the average time or the percentage.

Analyte monitoring system and method for determining system usage

An improved analyte monitoring system having a sensor and a transceiver with improved communication and/or user interface capabilities. The transceiver may communicate with and power the sensor. The transceiver may receive one or more analyte measurements from the sensor and may calculate one or more analyte concentrations based on the received analyte measurements. The transceiver may generate analyte concentration trends, alerts, and/or alarms based on the calculated analyte concentrations. The system may also include a display device, which may be, for example, a smartphone and may be used to display analyte measurements received from the transceiver. The display device may execute a mobile medical application. The system may include a data management system, which may be web-based.

Continuous analyte monitoring system

Methods, systems, and apparatuses for dynamic modification of calibration frequency. Dynamic modification of calibration frequency may include one or more of: receiving sensor data conveyed by an analyte sensor comprising an analyte indicator, using the sensor data to calculate one or more analyte levels, and receiving one or more reference analyte level measurements. Dynamic modification of calibration frequency may include using the sensor data, the one or more calculated analyte levels, and/or the one or more reference analyte level measurements to calculate a degradation rate of the analyte indicator of the analyte sensor. Dynamic modification of calibration frequency may include setting a dynamic calibration frequency based on the calculated degradation rate.

Dynamic modification of calibration frequency

An implantable device including a housing, circuitry within the housing, and a power source attached to the housing and electrically connected to the circuitry. The device may include electrically conductive connectors configured to electrically connect positive and negative terminals of the power source to the circuitry. The device may include a power source terminal enclosure attached to the power source and configured to enclose the positive and negative terminals of the power source. The power source terminal enclosure may include holes through which the electrically conductive connectors pass. The device may include a housing cap enclosure attached to the power source terminal enclosure and to an open end of the housing. The housing cap enclosure may enclose the circuitry within the housing and includes passages through which the electrically conductive connectors pass.

Enclosure for a wireless implantable device with embedded power source

A sensor, system, and method for detecting and correcting for an effect on an analyte indicator of an analyte sensor. The analyte indicator may be configured to exhibit a first detectable property that varies in accordance with an analyte concentration and an effect on (e.g., degradation of) the analyte indicator. The analyte sensor may also include an interferent indicator configured to exhibit a second detectable property (e.g., absorption) that varies in accordance the effect on the analyte indicator. The analyte sensor may generate (i) an analyte measurement based on the first detectable property exhibited by the analyte indicator and (ii) an interferent measurement based on the second detectable property exhibited by the interferent indicator. The analyte sensor may be part of a system that also includes a transceiver. The transceiver may use the analyte and interferent measurements to calculate an analyte level.

Detecting and correcting for interference in an analyte monitoring system

An analyte monitoring system may include an analyte sensor and a transceiver. The analyte sensor may include: a sensor housing, an analyte indicator on at least a portion of the sensor housing, a protective material on at least a portion of the analyte indicator, and a light source in the sensor housing and configured to emit excitation light to analyte indicator. The transceiver may be configured to receive the sensor measurements conveyed by the analyte sensor, infer information about a condition of the environment surrounding the analyte sensor, and calculate an analyte level using at least one or more of the sensor measurements and the inferred information about the condition of the environment surrounding the sensor. The protective material may have a thickness that is thin enough to allow at least some of the excitation light to pass through the protective material and into the environment surrounding the analyte sensor.

Analyte monitoring systems and methods that make use of information about a condition of the environment surrounding an analyte sensor

A sensing system including analyte sensing devices, an interface device, and shared communication device. The interface device may be configured to receive a power signal and generate power for powering the sensing devices and to convey data signals generated by the sensing devices. The sensing system may be configured to receive addressed and unaddressed commands. The sensing devices may be configured to perform activities (e.g., measurement sequences) in parallel in response to the unaddressed commands (e.g., unaddressed measurement commands). The sensing devices may be configured to only perform activities (e.g., conveying measurement data) in response to addressed commands (e.g., addressed read measurement data commands) if the sensing devices determine that the addressed commands are addressed to them. The sensing devices may be configured to perform different measurement sequences in response to an unaddressed measurement command to minimize interference caused by the sensing devices performing the measurement sequences in parallel.

Remotely-powered sensing system with multiple sensing devices

A transceiver for interfacing with an analyte sensor. The transceiver may include an interface device and a notification device. The interface device may be configured to convey a power signal to the analyte sensor and to receive data signals from the analyte sensor. The notification device may be configured to generate one or more of a vibrational, aural, and visual signal based on one or more data signals received from the analyte sensor. The interface device of the transceiver may receive analyte data from the analyte sensor, and the transceiver may comprise a processor configured to calculate an analyte concentration value based on the received analyte data. The notification device may be configured to generate one or more of aural, visual, or vibrational alarm when the calculated analyte concentration value exceeds or falls below a threshold value.

Analyte sensor transceiver configured to provide tactile, visual, and/or aural feedback

Disclosed are systems and methods for detecting analyte levels. These systems and methods may include a sensor configured for at least partial placement in an analyte-containing medium. The sensor may include one or more transducers and one or more diffusion barriers. The diffusion barriers may be arranged to delay diffusion of analyte to one transducer relative to another transducer. This delay may be used for purposes such as calculating and/or compensating for lag between a measured analyte level and a physiological analyte level of interest.

Methods and systems for calculating analyte levels

A sensor, system, and method for detecting and correcting for changes to an analyte indicator of an analyte sensor. The analyte indicator may be configured to exhibit a first detectable property that varies in accordance with an analyte concentration and an extent to which the analyte indicator has degraded. The analyte sensor may also include a degradation indicator configured to exhibit a second detectable property that varies in accordance with an extent to which the degradation indicator has degraded. The analyte sensor may generate (i) an analyte measurement based on the first detectable property exhibited by the analyte indicator and (ii) a degradation measurement based on the second detectable property exhibited by the degradation indicator. The analyte sensor may be part of a system that also includes a transceiver. The transceiver may use the analyte and degradation measurements to calculate an analyte level.

Detecting and correcting for changes to an analyte indicator

Disclosed are analyte monitoring systems and methods for calibrating an analyte sensor using one or more reference measurements. These systems and methods may include using a conversion function and first sensor data to calculate a first sensor analyte level, weighting a first reference analyte measurement (RM1) and one or more previous reference analyte measurements according to a weighted average cost function, updating the conversion function using the weighted RM1 and the one or more weighted previous reference analyte measurements as calibration points, and using the updated conversion function and second sensor data to calculate a second sensor analyte level. In some aspects, the systems and methods may include updating one or more of lag parameters used to calculate the sensor analyte levels.

Methods and systems for weighting calibration points and updating lag parameters

An analyte monitoring system may include an analyte sensor and a transceiver. The analyte sensor may include one or more sensors and a transceiver interface. The one or more sensors may be configured to generate sensor measurements indicative of an analyte level in a first medium. The sensors may include a temperature transducer configured to generate a sensor temperature measurement, and the sensor measurements may include the sensor temperature measurement. The transceiver interface may be configured to convey the sensor measurements. The transceiver may include a sensor interface and a processor. The sensor interface may be configured to receive the sensor measurements conveyed by the analyte sensor. The processor may be configured to adjust the sensor temperature measurement and calculate an analyte level in a second medium using at least the adjusted sensor temperature measurement and one or more of the sensor measurements.

Environmental detection and/or temperature compensation in an analyte monitoring system

Apparatuses and methods for improving the accuracy of an analyte sensor are disclosed. The sensor may include a photodetector and a low angle sensitive (LAS) optical filter. The photodetector may be configured to convert received light into current indicative of the intensity of the received light. The LAS optical filter may be configured to prevent light having a wavelength outside a band pass region from reaching the photodetector and to pass light having a wavelength within the band pass region to the photodetector. The percentage of light passing through the LAS optical filter may decrease as the angle of incidence of the light increases.

Integrated optical filter system with low sensitivity to high angle of incidence light for an analyte sensor

Sensors and methods for measurement of an analyte in a medium within a living animal are described. The sensor may include an inductive element that may receive power from an external device. The sensor may also include a charge storage device (CSD) and a memory. The sensor may perform analyte measurements initiated by the external device using power received from the external device and convey the analyte measurements to the external device using the inductive element. The sensor also may perform autonomous analyte measurements using the on board charge device's power and store the autonomous analyte measurements in the memory. The sensor may convey one or more stored analyte measurements to the external device using the inductive element using power received from the external device. The sensor may include a CSD-powered clock and a CSD-powered measurement scheduler that initiate the autonomous analyte measurements.

Analyte sensor

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Germantown, MD, United States of America

Andrew Dehennis