Centre National De La Recherche Scientifique

Ecole Superieure De Physique Et De Chimie Industrielles De La Ville De Paris

Other

The Broad Institute, Inc.

Universitè De Montpellier

UniversitÉde Strasbourg

Centre International De Recherche Aux Frontieres De La Chimie

Axlr, Satt Du Languedoc Roussillon

Chu Montpellier

Harvard College

Medical Research Council

Sorbonne Université

Institut Curie

Institut National De La Sante Et De La Recherche Medicale (inserm)

Paris Sciences Et Lettres

Andrew David Griffiths

Darren Roy Link

David A Weitz

Jerome Bibette

Keunho Ahn

Robert Nicol

Philippe Chi-Thanh Nghe

Clément Nizak

Jérôme Bibette

Alain Wagner

Patrick Tabeling

Fabrice Monti

Scott Steelman

Sylvain Ursuegui

Michael Ryckelynck

Jean-Marie Baudry

Klaus Eyer

Baptiste Saudemont

Catherine Michèle Marilou Alix-Panabieres

Elodie Michèle Christine Brient-Litzler

Timothy V Kirk

Alexei Godina

Elodie Michéle Christine Brient-Litzler

Jean Marie Pierre Baudry

Ketty Pernod

Marie Leman

Annabelle Gerard

David Weitz

Olivier Lantz

Antoine Masurier

Satyam Banerjee

Yvette Tran-amarelis

Marjan Abdorahim

Stéphane Chiron

Phillipe Nghe

Pablo Ibanez

Hubert Geisler

Gaël Blivet-bailly

Philippe Nghe

Sebastien Amigorena

Michaël Ryckelynck

Yannick Rondelez

Guillaume Gines

The disclosure provides methods and compositions useful for labeling of target molecules with origin-specific nucleic acid identifiers (for example, barcodes), which can be used subsequently to identify, quantify, or otherwise characterize a feature or activity of target molecules originating from a particular discreet volume. Such target molecules can include polypeptides expressed by cells, in which nucleic acid molecules encoding the polypeptides are labeled with the same, or matched, origin-specific nucleic acid identifiers.

Proteomic analysis with nucleic acid identifiers

The present invention relates to the field of biological diagnosis in oncology. It relates to a method and apparatus for detecting and/or characterizing tumor cells by detecting one or more elements of the tumor cell secretome, in particular one or more peptides or proteins, and, in particular, one or more tumor markers. The invention also relates to detecting and/or characterizing droplets of tumor cells and their method of preparation.

Method for detecting and/or characterising tumour cells and associated apparatus

The present invention relates to systems and methods for manipulating droplets within a high through put microfluidic system.

High-throughput dynamic reagent delivery system

The present invention relates to a method for capturing a molecular target present in the aqueous phase of a water-in-oil emulsion, said method being based on the use of a binding system comprising (a) a surfactant bearing a functional moiety on its hydrophilic head group and (b) a chemoprobe that acts as a molecular staple between the functionalized surfactant and the molecular target and comprises at least two distinct domains namely (i) at least one capture moiety which is able to specifically bind the molecular target and (ii) at least one binding domain which is able to interact with the functional group of the surfactant through covalent or non-covalent interactions, directly or through a binding intermediary.

Intra-droplet surface engineering to capture a molecular target

The invention concerns a method of analyzing the content of drops, involving then following step: The method involves a step in which a physical parameter characteristic of the attachment of the target element to the aggregate () is measured.

Method of analyzing the content of drops and associated apparatus

Growing community of inventors

Paris, France

Andrew David Griffiths