Medical Research Council

Harvard College

Other

Cambridge Antibody Technology Limited

United Kingdom Research and Innovation

Medimmune Limited

Bio-rad Laboratories, Inc.

Domantis Limited

National Science Foundation

454 Life Sciences Corporation

University of Strasbourg

Andrew David Griffiths

Gregory Paul Winter

James David Marks

Kevin Stuart Johnson

John Gerald McCafferty

Darren Roy Link

David A Weitz

Jerome Bibette

Keunho Ahn

Anthony Richard Pope

Ronald Henry Jackson

Timothy Peter Bonnert

Kaspar Philipp Holliger

David John Chiswell

Timothy Piers Clackson

Dan S Tawfik

Geoffrey Walter Grigg

Hendricus Renerus Jacobus Mattheus Hoogenboom

Henricus Renerus Jacobus Mattheus Hoogenboom

Chris Abell

Andrew John Smith

Florian Hollfelder

Enrico Mastrobattista

Peter Michael Waterhouse

Brian Timothy McGuinness

Magnus Malmqvist

Armin Sepp

Terence Derek Prospero

Ahuva Nissim

Andrew John Hammond Smith

Hendricus Renerus Hoogenboom

Kaspar-Philipp Holliger

Hendricus Renerus Jacobus Matheus Hoogenboom

Samuel Cameron Williams

Abdeslam El Harrak

Henricus Renerus Hoogenboom

François Caron

Igor Fisch

Felix Kleinschmidt

Eric Brouzes

Victoire Goust

Thomas Mangeat

Kaspar-Philip Holliger

Hendricus Reneus Jacobus Mattheus Hoogenboom

Kasper Philipp Holliger

Dan Tawfik

Kuenho Ahn

Chris Department Of Chemistry Abell

Hendricus Renerus Jacobus M Hoogenboom

The invention describes a method for the synthesis of compounds comprising the steps of: (a) compartmentalising two or more sets of primary compounds into microcapsules; such that a proportion of the microcapsules contains two or more compounds; and (b) forming secondary compounds in the microcapsules by chemical reactions between primary compounds from different sets; wherein one or both of steps (a) and (b) is performed under microfluidic control; preferably electronic microfluidic control The invention further allows for the identification of compounds which bind to a target component of a biochemical system or modulate the activity of the target, and which is co-compartmentalised into the microcapsules.

Compartmentalised combinatorial chemistry by microfluidic control

The invention describes a method for isolating one or more genetic elements encoding a gene product having a desired activity, comprising the steps of: (a) compartmentalising genetic elements into microcapsules; and (b) sorting the genetic elements which express the gene product having the desired activity; wherein at least one step is under microfluidic control. The invention enables the in vitro evolution of nucleic acids and proteins by repeated mutagenesis and iterative applications of the method of the invention.

Vitro evolution in microfluidic systems

The present invention generally relates to systems and methods to create stable emulsions with low rates of exchange of molecules between microdroplets.

Microfluidic systems and methods for reducing the exchange of molecules between droplets

The invention describes a method for the identification of compounds which bind to a target component of a biochemical system or modulate the activity of the target, comprising the steps of: a) compartmentalising the compounds into microcapsules together with the target, such that only a subset of the repertoire is represented in multiple copies in any one microcapsule; and b) identifying the compound which binds to or modulates the activity of the target; wherein at least one step is performed under microfluidic control. The invention enables the screening of large repertoires of molecules which can serve as leads for drug development.

Compartmentalised screening by microfluidic control

In vitro evolution in microfluidic systems

The present invention relates to labelled silica-based nanoparticles with enhanced properties, to process for preparing them and to uses thereof.

Labelled silica-based nanomaterial with enhanced properties and uses thereof

The invention describes a method for the identification of compounds which bind to a target component of a biochemical system or modulate the activity of the target, comprising the steps of: a) compartmentalizing the compounds into microcapsules together with the target, such that only a subset of the repertoire is represented in multiple copies in any one microcapsule; and b) identifying the compound which binds to or modulates the activity of the target; wherein at least one step is performed under microfluidic control. The invention enables the screening of large repertoires of molecules which can serve as leads for drug development.

The invention describes a method for the identification of compounds which bind to a target component of a biochemical system or modulate the activity of the target, by compartmentalizing the compounds into microcapsules together with the target, such that only a subset of the repertoire is represented in multiple copies in any one microcapsules; and identifying the compound which binds to or modulates the activity of the target. The invention enables the screening of large repertoires of molecules which can serve as leads for drug development.

Selection by compartmentalized screening

Methods for use in the synthesis and identification of molecules which bind to a target component of a biological system or modulate the activity of a target are described.

Method of synthesis and testing of combinatorial libraries using microcapsules

The invention describes a method for the synthesis of compounds comprising the steps of: (a) compartmentalizing two or more sets of primary compounds into microcapsules; such that a proportion of the microcapsules contains two or more compounds; and (b) forming secondary compounds in the microcapsules by chemical reactions between primary compounds from different sets; wherein one or both of steps (a) and (b) is performed under microfluidic control; preferably electronic microfluidic control The invention further allows for the identification of compounds which bind to a target component of a biochemical system or modulate the activity of the target, and which is co-compartmentalized into the microcapsules.

Selection by compartmentalised screening

The invention describes a method for the synthesis of compounds comprising the steps of: (a) compartmentalising two or more sets of primary compounds into microcapsules; such that a proportion of the microcapsules contains two or more compounds; and (b) forming secondary compounds in the microcapsules by chemical reactions between primary compounds from different sets; wherein one or both of steps (a) and (b) is performed under microfluidic control; preferably electronic microfluidic control, The invention further allows for the identification of compounds which bind to a target component of a biochemical system or modulate the activity of the target, and which is co-compartmentalised into the microcapsules.

The invention describes a method for isolating one or more genetic elements encoding a gene product having a desired activity, comprising of the steps of: (a) compartmentalizing genetic elements into microcapsules; (b) expressing the genetic elements to produce their respective gene products within the microcapsules; (c) sorting the genetic elements which produce the gene product having a desired activity. The invention enables the in vitro evolution of nucleic acids by repeated mutagenesis and iterative applications of the method of the invention.

In vitro sorting method

Growing community of inventors

Cambridge, United Kingdom

Andrew David Griffiths