The Charles Stark Draper Laboratory, Inc.

Andrew Czarnecki

Jesse J Wheeler

Jonathan Jay Bernstein

Bryan McLaughlin

Amy Elizabeth Duwel

Daniel Kenneth Freeman

John Lachapelle

Anilkumar Harapanahalli Achyuta

Brian Nugent

Brett Ingersoll

Brian Daniels

Reed Irion

Carlos A Segura

Daniel Joseph Guyon

Matthew C Muresan

James E Moran

Caroline K Bjune

John R Burns, Iv

Marc W McConley

Brent Hollosi

Matthew Muresan

John R Burns

Robert A Bousquet

Philip D Parks

Robert Bousquet

Keith B Baldwin

David Goldberg

Alex Kindle

Wes T Uy

John R Lachapelle

Elliot H Greenwald

Alejandro J Miranda

Jake G Hellman

John Roland Lachapelle

The systems and methods described herein include an external base station with a tethered transceiver, an implanted hub that includes power, telemetry, and processing electronics, and a plurality of implanted satellite that contain reconfigurable front-end electronics for interfacing with electrodes. The system can operate in different modes. In a first mode, called a base boost mode, the external base station is used for closed-loop control of stimulation therapies. In a second, autonomous mode, closed-loop control is performed in the hub without direct influence from the base station. In a third mode, streams of neural data are transmitted to an offline processor for offline analysis.

Implantable hub and satellite system for neural recording and stimulation

This disclosure provides systems and methods for delivering a neural stimulation pulse. A neural implant device can include an energy harvesting circuit configured to receive an input signal and generate an electrical signal based on the received input signal. A diode rectifier in series with the energy harvesting circuit can rectify the electrical signal. The energy harvesting circuit and the diode rectifier can be encapsulated within a biocompatible electrically insulating material. A neural electrode can be exposed through the biocompatible electrically insulating material. The neural electrode can be configured to deliver a neural stimulation pulse. The neural implant device can have a volume that is less than about 1.0 cubic millimeter.

Neural implant for microstimulation

A multi-layered electronic device including two or more stacked metal conducting layers, a dielectric layer disposed between metal conducting layers, and at least one electrical connection extending between contact pads of metal conducting layers and through a through hole of the dielectric layer is provided. A system including at least one multi-layered electronic device, a satellite coupled to at least one multi-layered electronic device, and a controller hub electrically connected to the multi-layered electronic device via the satellite is also provided. A method of manufacturing the multi-layered electronic device including forming first and second first metal conducting layers, depositing a dielectric layer adjacent to the metal conducting layers, and connecting the metal conducting layers is also provided.

Multi-layered fabrication processing

The present disclosure describes systems and methods for improving the safety of bio-implantable electronics systems used for recording and electrical stimulation applications. The present disclosure discusses a communication protocol that provides DC balanced, bi-directional communication between a controller hub and satellite electrical stimulation and recording devices distributed throughout the patient's body. The present disclosure also describes a system for detecting and preventing current leaks along electrical pathways that may pass into a patient.

Integrated power delivery, communication, and health monitoring system for implantable electrode

Systems and methods are disclosed herein for recording electrical signals in the presence of artifacts. The system and methods can employ multiple techniques for attenuating large, unwanted artifacts while preserving lower amplitude desirable signals. Aspects that can improve the recording of electrical signals in the presence of larger artifacts include particular electrode placement and spacing, high dynamic range amplification with good linearity, and signal blanking. Combinations of more or fewer techniques can be employed to achieve the desired attenuation of signal artifacts while preserving the desired signal. The systems and methods are suitable for recording neural signals in the presence of electrical stimulation signals.

Apparatus and method for recording neural signals in the presence of artifacts

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Cambridge, MA, United States of America

Andrew Czarnecki