Constellation Pharmaceuticals, Inc.

Eisai R&d Management Co., Ltd.

Other

Axovant Sciences Gmbh

Denali Therapeutics Inc.

Andrew Cook

James E Audia

Christopher G Nasveschuk

Jean-Christophe P Harmange

Brian K Albrecht

Victor S Gehling

Dominic J Reynolds

Rishi G Vaswani

Sudeep Prajapati

Les A Dakin

Xiang Liu

James Palacino

Shelby Ellery

Duane A Burnett

Martin Duplessis

Matthew Gregory Bursavich

Bryce Alden Harrison

Andrew J McRiner

Raksha A Acharya

Thiwanka Samarakoon

Megan Sheehan

Nathan Elliott Fishkin

Ping Zhu

Peter G Smith

Silvia Buonamici

Lihua Yu

Ermira Pazolli

Michael W Seiler

Yonghong Xiao

Nicholas Calandra

Zhenhua Wu

Jason T Lowe

Shouyong Peng

John JianShi Wang

Guo Zhu Zheng

Ming-Hong Hao

Atsushi Endo

Yoshihiko Kotake

Gregg F Keaney

Kazunobu Kira

Marta Nevalainen

Parcharee Tivitmahaisoon

Cheng Zhong

Michael Jon Scott

Norio Murai

Alexandre Côté

Baudouin Gerard

Gerhard Koenig

Satoshi Nagao

Masayuki Miyano

Kenzo Arai

Alexandre Gagnon

Regina Mikie Kanada Sonobe

Nicholas C Gearhart

Lisa A Marcaurelle

Joel D St John

Ryan Brawn

Morgan Welzel O'shea

Tuoping Luo

Linker-drug compounds and antibody-drug conjugates that bind to human oncology targets are disclosed. The linker-drug compounds and antibody-drug conjugates comprise a splicing modulator drug moiety. The disclosure further relates to methods and compositions for use in the treatment of neoplastic disorders by administering the antibody-drug conjugates provided herein. In an embodiment, the splicing modulator comprises a pladienolide or a pladienolide derivative.

Splicing modulator antibody-drug conjugates and methods of use

The present disclosure provides novel pladienolide compounds, pharmaceutical compositions containing such compounds, and methods for using the compounds as therapeutic agents. These compounds may be useful in the treatment of cancers, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful. Also provided herein are methods of treating cancers by administering at least one compound disclosed herein and at least one additional therapy.

Certain pladienolide compounds and methods of use

The present disclosure provides pladienolide compounds, pharmaceutical compositions containing such compounds, and pladienolide compounds for use in methods of medical treatment. These compounds may be useful in the treatment of cancer, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful. Also provided herein are pladienolide compounds for use in methods of treating cancers by administering at least one pladienolide compound disclosed herein and at least one additional therapy

Certain aryl pladienolide compounds and methods of use

An improved three-dimensional structure and method and system of making same is provided, wherein the method for forming the three-dimensional structure comprises: coating a filament with a curable resin; directing a first portion of the coated filament around a plurality of pins fixed to and extending outwardly from a frame, the coated filament directed to intersect according to a pre-set pattern, the coated filament forming a first filament layer; directing a second portion of the coated filament about said pins forming one or more subsequent filament layers aligned and in contact with the first filament layer, the filament layers collectively forming a filament stack, the filament stack having a predetermined height and defining the intersecting panel elements; and curing the curable resin such that it hardens and retains the individual filament layers forming the filament stack in a three-dimensional shape.

Three-dimensional structure and method and system of making same

A hanger for suspending tiles or panels from a ceiling or roof, and a ceiling system incorporating the hanger, is provided. The hanger comprises a suspension member securable to the ceiling, having a longitudinal axis, and a panel mount coupled to the suspension member and releasably securable to each of a multiple panels to hold the multiple panels in a spaced relation from the ceiling on a common plane.

Ceiling system and hanger for suspending ceiling tiles or panels therefrom

A hanger and a ceiling suspension system incorporating the hanger, for suspending a suspension rail from a ceiling are provided, where the suspension rail is configured to support an object. The hanger includes a first suspension member and a second suspension member positioned adjacent to one another. The first and second suspension members each have an upper portion, a lower portion, and a coupling component situated between the upper and lower portions. The upper portions are configured to be releasably suspended from the ceiling. The lower portions are configured to releasably engage the suspension rail. The coupling components are engageable to form a hinge connection between the first and second suspension members. Separation of the upper portions from one another biases the lower portions towards one another to releasably engage the suspension rail between the suspension members.

Clip hanger and ceiling suspension system incorporating same

The present invention relates to novel geminal substituted aminobenzisoxazole compounds, and pharmaceutical compositions of the same, that are suitable as agonists or partial agonists of &#x3b1;7-nAChR, and methods of preparing these compounds and compositions, and the use of these compounds and compositions in methods of maintaining, treating and/or improving cognitive function. In particular, methods of administering the compound or composition to a patient in need thereof, for example a patient with a cognitive deficiency and/or a desire to enhance cognitive function, that may derive a benefit therefrom.

Geminal substituted aminobenzisoxazole compounds as agonists of &#x3b1;7-nicotinic acetylcholine receptors

The present invention relates to novel aminobenzisoxazole compounds, and pharmaceutical compositions of the same, that are suitable as agonists or partial agonists of Alpha7-nAChR, and methods of preparing these compounds and compositions, and the use of these compounds and compositions in methods of maintaining, treating and/or improving cognitive function. In particular, methods of administering the compound or composition to a patient in need thereof, for example a patient with a cognitive deficiency and/or a desire to enhance cognitive function, that may derive a benefit therefrom.

Aminobenzisoxazole compounds as agonists of &#x3b1;7-nicotinic acetylcholine receptors

The present invention relates to novel geminal substituted quinuclidine amide compounds, and pharmaceutical compositions of the same, that are suitable as agonists or partial agonists of &#x3b1;7-nAChR, and methods of preparing these compounds and compositions, and the use of these compounds and compositions in methods of maintaining, treating and/or improving cognitive function. In particular, methods of administering the compound or composition to a patient in need thereof, for example a patient with a cognitive deficiency and/or a desire to enhance cognitive function, that may derive a benefit therefrom.

Geminal substituted quinuclidine amide compounds as agonists of &#x3b1;-7 nicotonic acetylcholine receptors

Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.

Modulators of methyl modifying enzymes, compositions and uses thereof

The present disclosure relates to oxadiazine compounds, pharmaceutical compositions comprising an effective amount of an oxadiazine compound and methods for using an oxadiazine compound in the treatment of a neurodegenerative disease, comprising administering to a subject in need thereof an effective amount of an oxadiazine compound.

Oxadiazine compounds and methods of use thereof

Growing community of inventors

Stow, MA, United States of America

Andrew Cook